亚努卡胺A的全合成及立体化学修正
The total synthesis and stereochemical revision of yanucamide A.
作者信息
Xu Zhengshuang, Peng Yungui, Ye Tao
机构信息
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
出版信息
Org Lett. 2003 Aug 7;5(16):2821-4. doi: 10.1021/ol034803d.
PMID:12889883
Abstract
[reaction: see text] The first total synthesis of yanucamide A is reported via amide and ester couplings of the key components. This synthesis has established the configuration at the previously ambiguous 3-position, and also revised the stereochemistry at the 22-position, to give 3S,12S,17S,22S for the natural product.
摘要
[反应：见正文] 据报道，通过关键组分的酰胺和酯偶联反应首次实现了鸭嘴花酰胺A的全合成。该合成确定了之前结构不明确的3位构型，还修正了22位的立体化学，得到天然产物的3S,12S,17S,22S构型。
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