Xu Zhengshuang, Peng Yungui, Ye Tao
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Org Lett. 2003 Aug 7;5(16):2821-4. doi: 10.1021/ol034803d.
[reaction: see text] The first total synthesis of yanucamide A is reported via amide and ester couplings of the key components. This synthesis has established the configuration at the previously ambiguous 3-position, and also revised the stereochemistry at the 22-position, to give 3S,12S,17S,22S for the natural product.
[反应：见正文] 据报道，通过关键组分的酰胺和酯偶联反应首次实现了鸭嘴花酰胺A的全合成。该合成确定了之前结构不明确的3位构型，还修正了22位的立体化学，得到天然产物的3S,12S,17S,22S构型。
