13C 标记揭示了新型聚酮聚胺抗生素泽胺素生物合成过程中的多种胺化反应。
13C labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae.
机构信息
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673.
出版信息
Chem Commun (Camb). 2010 Jan 14;46(2):333-5. doi: 10.1039/b916307g. Epub 2009 Nov 13.
DOI:10.1039/b916307g
PMID:20024369
Abstract
The structure of zeamine, a novel polyamino-amide antibiotic metabolite of Dickeya zeae has been established by NMR and detailed MS analyses; labelling studies with (13)C-labelled acetates suggest that the repeating secondary amine containing motif may be biosynthesised via a modular PKS containing aminotransferase domains.
摘要
Dickeya zeae 的一种新型聚氨基酰胺抗生素代谢产物 zeamine 的结构已通过 NMR 和详细的 MS 分析确定；用（13）C 标记的醋酸盐进行的标记研究表明，含重复仲胺的基序可能通过含有氨基转移酶结构域的模块化 PKS 生物合成。
Zotero 插件