抗生素致聋的遗传学因素：线粒体遗传
Genetic aspects of antibiotic induced deafness: mitochondrial inheritance.
作者信息
Hu D N, Qui W Q, Wu B T, Fang L Z, Zhou F, Gu Y P, Zhang Q H, Yan J H, Ding Y Q, Wong H
机构信息
Department of Genetic Counselling, Tiedao Medical College, Shanghai, China.
出版信息
J Med Genet. 1991 Feb;28(2):79-83. doi: 10.1136/jmg.28.2.79.
Abstract
Analysis of 36 pedigrees with a positive family history of aminoglycoside antibiotic induced deafness, ascertained in a population of 483,611 in Zhabei District in Shanghai, showed that the susceptibility to antibiotic ototoxicity was transmitted by females exclusively, indicating mitochondrial inheritance. Reanalysis of 18 other published pedigrees confirmed this conclusion.
摘要
对在上海闸北区483,611人中确定的36个有氨基糖苷类抗生素致聋家族史的家系进行分析，结果显示对抗生素耳毒性的易感性仅通过女性传递，表明为线粒体遗传。对其他18个已发表家系的重新分析证实了这一结论。
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