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1
Genetic aspects of antibiotic induced deafness: mitochondrial inheritance.抗生素致聋的遗传学因素：线粒体遗传
J Med Genet. 1991 Feb;28(2):79-83. doi: 10.1136/jmg.28.2.79.
2
A molecular basis for human hypersensitivity to aminoglycoside antibiotics.人类对氨基糖苷类抗生素超敏反应的分子基础。
Nucleic Acids Res. 1993 Sep 11;21(18):4174-9. doi: 10.1093/nar/21.18.4174.
3
[Screening for mitochondrial 1555(G) mutation in patients with aminoglycoside antibiotic-induced deafness].[氨基糖苷类抗生素致聋患者线粒体1555(G)突变的筛查]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1999 Jun;16(3):141-4.
4
Mitochondrial ribosomal RNA gene mutation in a patient with sporadic aminoglycoside ototoxicity.一名散发性氨基糖苷类耳毒性患者的线粒体核糖体RNA基因突变
Am J Otolaryngol. 1993 Nov-Dec;14(6):399-403. doi: 10.1016/0196-0709(93)90113-l.
5
Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness.与抗生素诱导性和非综合征性耳聋相关的线粒体核糖体RNA突变
Nat Genet. 1993 Jul;4(3):289-94. doi: 10.1038/ng0793-289.
6
[Aminoglycoside ototoxicity associated with mitochondrial DNA mutation].与线粒体DNA突变相关的氨基糖苷类耳毒性
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 1999 May;13(5):195-7.
7
[Familial susceptibility to aminoglycoside ototoxicity due to the A1555G mutation in the mitochondrial DNA].[线粒体DNA中A1555G突变导致的氨基糖苷类耳毒性家族易感性]
Med Clin (Barc). 2003 Jul 12;121(6):216-8. doi: 10.1016/s0025-7753(03)73909-8.
8
[Screening for the 1555G mutation in mitochondrial DNA in pedigrees with aminoglycoside antibiotic induced deafness].[对氨基糖苷类抗生素致聋家系中线粒体DNA 1555G突变的筛查]
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1998 Apr;33(2):67-70.
9
Clinical evaluation and mitochondrial DNA sequence analysis in two Chinese families with aminoglycoside-induced and non-syndromic hearing loss.两个中国家庭氨基糖苷类药物所致非综合征性听力损失的临床评估及线粒体DNA序列分析
Biochem Biophys Res Commun. 2005 Oct 28;336(3):967-73. doi: 10.1016/j.bbrc.2005.08.199.
10
Mutation in the mitochondrial 12S rRNA gene in two families from Mongolia with matrilineal aminoglycoside ototoxicity.来自蒙古的两个母系遗传氨基糖苷类耳毒性家族的线粒体12S rRNA基因突变。
J Med Genet. 1997 Feb;34(2):169-72. doi: 10.1136/jmg.34.2.169.

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1
Rapid point of care testing: the next frontier in pharmacogenomics.即时快速检测：药物基因组学的下一个前沿领域。
Pharmacogenomics. 2024;25(7):289-291. doi: 10.1080/14622416.2024.2366691. Epub 2024 Jul 23.
2
Our current understanding of the toxicity of altered mito-ribosomal fidelity during mitochondrial protein synthesis: What can it tell us about human disease?我们目前对线粒体蛋白质合成过程中线粒体核糖体保真度改变的毒性的理解：它能告诉我们哪些关于人类疾病的信息？
Front Physiol. 2023 Jun 30;14:1082953. doi: 10.3389/fphys.2023.1082953. eCollection 2023.
3
Structural analysis of mitochondrial rRNA gene variants identified in patients with deafness.对耳聋患者中鉴定出的线粒体rRNA基因变异的结构分析。
Front Physiol. 2023 Jun 8;14:1163496. doi: 10.3389/fphys.2023.1163496. eCollection 2023.
4
Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care.快速床边基因分型以避免新生儿重症监护中氨基糖苷类药物引起的耳毒性。
JAMA Pediatr. 2022 May 1;176(5):486-492. doi: 10.1001/jamapediatrics.2022.0187.
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Genetic testing in the acute setting: a round table discussion.急性病诊治中的基因检测：圆桌讨论。
J Med Ethics. 2020 Aug;46(8):531-532. doi: 10.1136/medethics-2019-106043. Epub 2020 Jul 10.
6
Aminoglycosides rapidly inhibit NAD(P)H metabolism increasing reactive oxygen species and cochlear cell demise.氨基糖苷类药物可迅速抑制 NAD(P)H 代谢，增加活性氧自由基，导致耳蜗细胞死亡。
J Biomed Opt. 2018 Nov;24(5):1-14. doi: 10.1117/1.JBO.24.5.051403.
7
Aminoglycoside-Induced Cochleotoxicity: A Review.氨基糖苷类药物所致耳毒性：综述
Front Cell Neurosci. 2017 Oct 9;11:308. doi: 10.3389/fncel.2017.00308. eCollection 2017.
8
Study of streptomycin-induced ototoxicity: protocol for a longitudinal study.链霉素诱导耳毒性的研究：一项纵向研究方案。
Springerplus. 2016 Jun 17;5(1):758. doi: 10.1186/s40064-016-2429-5. eCollection 2016.
9
New treatment options for hearing loss.听力损失的新治疗选择。
Nat Rev Drug Discov. 2015 May;14(5):346-65. doi: 10.1038/nrd4533. Epub 2015 Mar 20.
10
Mitochondrial mutation m.1555A>G as a risk factor for failed newborn hearing screening in a large cohort of preterm infants.线粒体突变m.1555A>G作为一大群早产儿新生儿听力筛查失败的危险因素。
BMC Pediatr. 2014 Aug 26;14:210. doi: 10.1186/1471-2431-14-210.

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Streptomycin ototoxicity in the unborn child.未出生胎儿的链霉素耳毒性。
S Afr Med J. 1981 Aug 22;60(8):316-8.
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Altered ribosomal RNA genes in mitochondria from mammalian cells with chloramphenicol resistance.来自具有氯霉素抗性的哺乳动物细胞的线粒体中核糖体RNA基因的改变。
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Sequence and organization of the human mitochondrial genome.人类线粒体基因组的序列与组织
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Mitochondrial inheritance in a mitochondrially mediated disease.线粒体介导疾病中的线粒体遗传
N Engl J Med. 1983 Jul 21;309(3):142-6. doi: 10.1056/NEJM198307213090304.
6
Familial aggregation of streptomycin ototoxicity: autosomal dominant inheritance?链霉素耳毒性的家族聚集性：常染色体显性遗传？
J Med Genet. 1983 Oct;20(5):357-60. doi: 10.1136/jmg.20.5.357.
7
Concordance for drug-induced aplastic anemia in identical twins.同卵双胞胎药物性再生障碍性贫血的一致性。
N Engl J Med. 1969 Jul 3;281(1):7-11. doi: 10.1056/NEJM196907032810102.
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Familial occurrence of drug-induced hearing loss.药物性听力损失的家族性发病情况。
Am J Dis Child. 1974 Feb;127(2):245-7. doi: 10.1001/archpedi.1974.02110210095014.
9
Familial incidence of streptomycin hearing loss and hereditary weakness of the cochlea.链霉素所致听力损失的家族发病率及耳蜗遗传性衰弱
Audiology. 1971 Sep-Dec;10(5):315-22. doi: 10.3109/00206097109072568.
10
Deletions of mitochondrial DNA in Kearns-Sayre syndrome.卡恩斯-塞尔综合征中线粒体DNA的缺失。
Neurology. 1988 Sep;38(9):1339-46. doi: 10.1212/wnl.38.9.1339.

抗生素致聋的遗传学因素：线粒体遗传

Genetic aspects of antibiotic induced deafness: mitochondrial inheritance.

作者信息

Hu D N, Qui W Q, Wu B T, Fang L Z, Zhou F, Gu Y P, Zhang Q H, Yan J H, Ding Y Q, Wong H

机构信息

Department of Genetic Counselling, Tiedao Medical College, Shanghai, China.

出版信息

J Med Genet. 1991 Feb;28(2):79-83. doi: 10.1136/jmg.28.2.79.

DOI:10.1136/jmg.28.2.79
PMID:2002491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1016772/
Abstract

Analysis of 36 pedigrees with a positive family history of aminoglycoside antibiotic induced deafness, ascertained in a population of 483,611 in Zhabei District in Shanghai, showed that the susceptibility to antibiotic ototoxicity was transmitted by females exclusively, indicating mitochondrial inheritance. Reanalysis of 18 other published pedigrees confirmed this conclusion.

摘要

对在上海闸北区483,611人中确定的36个有氨基糖苷类抗生素致聋家族史的家系进行分析，结果显示对抗生素耳毒性的易感性仅通过女性传递，表明为线粒体遗传。对其他18个已发表家系的重新分析证实了这一结论。