Viljoen D L, Sellars S L, Beighton P
J Med Genet. 1983 Oct;20(5):357-60. doi: 10.1136/jmg.20.5.357.
Eight members of a large kindred of mixed ancestry from a remote rural area of South Africa were investigated for deafness. In each, severe permanent perceptive hearing loss had developed during antituberculous therapy with streptomycin sulphate in conventional doses. Although unproven by the data available in this study, the familial aggregation and pattern of distribution of sensitivity to streptomycin suggested autosomal dominant inheritance.
对来自南非偏远农村地区的一个有混合血统的大家族中的8名成员进行了耳聋调查。他们每个人在接受常规剂量硫酸链霉素抗结核治疗期间都出现了严重的永久性感音神经性听力损失。尽管本研究现有数据尚未证实,但对链霉素敏感性的家族聚集性和分布模式提示为常染色体显性遗传。