Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
J Biochem Mol Toxicol. 2009 Nov-Dec;23(6):387-93. doi: 10.1002/jbt.20302.
This article reports data on the preventive effect of (-)epigallocatechin gallate (EGCG) on lipid metabolism and lipoproteins in isoproterenol (ISO)-induced myocardial infarction (MI) in Wistar rats. The rats were induced MI by ISO (100 mg/kg) at an interval of 24 h for 2 days. EGCG (30 mg/kg) was given to rats as pretreatment for 21 days orally using an intragastric tube. EGCG significantly reduced the increased serum levels of cholesterol, triglycerides, and free fatty acids in the heart and serum phospholipids (PLs) in ISO-treated rats. It also significantly increased the reduced levels of heart PLs in ISO-induced rats. EGCG reduced the levels of serum low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol and increased serum high-density lipoprotein (HDL)-cholesterol in ISO-treated rats. It also reduced the increased cholesterol/PL ratio and atherogenic index and significantly increased the reduced ratio of HDL-cholesterol/total cholesterol. Also EGCG significantly increased the reduced activity of lecithin cholesterol acyl transferase in ISO-treated rats. Thus, EGCG prevented the accumulation of lipids and altered the levels of lipoproteins in myocardial-infarcted rats.
本文报道了表没食子儿茶素没食子酸酯（EGCG）对异丙肾上腺素（ISO）诱导的 Wistar 大鼠心肌梗死（MI）模型中脂代谢和脂蛋白的预防作用的数据。大鼠通过 ISO（100mg/kg）间隔 24 小时两次腹腔注射诱导 MI。EGCG（30mg/kg）通过灌胃预处理大鼠 21 天，每天一次。EGCG 显著降低 ISO 处理大鼠心脏和血清中胆固醇、甘油三酯和游离脂肪酸以及血清磷脂（PL）水平的升高。它还显著增加了 ISO 诱导的大鼠心脏 PL 水平的降低。EGCG 降低了 ISO 处理大鼠血清中低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇的水平，并增加了血清高密度脂蛋白（HDL）-胆固醇的水平。它还降低了胆固醇/PL 比值和动脉粥样硬化指数，并显著增加了 HDL-胆固醇/总胆固醇比值的降低。此外，EGCG 还显著增加了 ISO 处理大鼠卵磷脂胆固醇酰基转移酶活性的降低。因此，EGCG 可防止脂质在心肌梗死大鼠中的积累，并改变脂蛋白的水平。
