Takahashi K, Murakami S, Chikashige Y, Niwa O, Yanagida M
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
J Mol Biol. 1991 Mar 5;218(1):13-7. doi: 10.1016/0022-2836(91)90867-6.
We report here that the fission yeast centromere regions in the three chromosomes contain no less than 36 symmetrically arranged tRNA-coding sequences, and many of them are located within the inner inverted regions that are thought to be essential for the centromere function. There are 11 different species of tRNA-coding sequences, and four of them are identical to those previously known in this organism. This high-density distribution of tRNA genes in the centromere regions is surprising, as the fission yeast centromeres were thought to form transcriptionally inactive structures.
我们在此报告，裂殖酵母三条染色体的着丝粒区域包含不少于36个对称排列的tRNA编码序列，其中许多位于内部反向区域内，这些区域被认为对着丝粒功能至关重要。有11种不同的tRNA编码序列，其中四种与该生物体中先前已知的序列相同。tRNA基因在着丝粒区域的这种高密度分布令人惊讶，因为裂殖酵母着丝粒被认为形成转录不活跃的结构。
