职业因素与帕金森病风险：一项基于人群的病例对照研究。
Occupational factors and risk of Parkinson's disease: A population-based case-control study.
机构信息
Department of Neurology, University of Washington, Seattle, USA.
出版信息
Am J Ind Med. 2010 Mar;53(3):217-23. doi: 10.1002/ajim.20788.
Abstract
BACKGROUND
Parkinson's disease (PD) has been associated with various workplace factors, but the evidence is inconsistent.
OBJECTIVE
To estimate the risk of PD associated with various jobs and workplace exposures.
METHODS
We conducted a population-based, case-control study of 404 incident PD cases and 526 age and sex-matched controls, collecting self-reported work histories including job titles and exposures to various industrial toxicants. Relative risks of PD from these exposures were estimated with odds ratios (OR) and 95% confidence intervals (CI) using logistic regression.
RESULTS
Risk was not significantly affected by farming work, by metal work, or by exposure to pesticides, metals, or solvents.
CONCLUSIONS
These findings do not provide support for the hypothesis that workplace factors affect the risk of PD.
摘要
背景
帕金森病（PD）与各种工作场所因素有关，但证据不一致。
目的
评估与各种工作和工作场所暴露相关的 PD 风险。
方法
我们进行了一项基于人群的病例对照研究，纳入了 404 例新发 PD 病例和 526 名年龄和性别匹配的对照，收集了包括职业和接触各种工业毒物在内的自我报告的工作经历。使用逻辑回归估计这些暴露与 PD 的相对风险，采用比值比（OR）和 95%置信区间（CI）表示。
结果
与农业工作、金属工作或接触农药、金属或溶剂相关的风险没有显著增加。
结论
这些发现不支持工作场所因素影响 PD 风险的假设。
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