Max-Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D-37077 Göttingen, Germany.
Mol Cell Endocrinol. 2010 Jul 8;323(1):62-9. doi: 10.1016/j.mce.2009.12.016. Epub 2009 Dec 16.
Due to the increasing prevalence of type 1 diabetes and the complications arising from actual therapies, alternative treatments need to be established. In order to compensate the beta-cell deficiency associated with type 1 diabetes, current researches focus on new strategies to generate insulin-producing beta cells for transplantation purpose, including the differentiation of stem or progenitor cells, as well as the transdifferentiation of dispensable mature cell types. However, to successfully force any cell to adopt a functional beta-cell fate or phenotype, a better understanding of the molecular mechanisms underlying the genesis of these in vivo is required. The present short review summarizes the hitherto known functions and interplays of several key factors involved in the differentiation of the endocrine cell lineages during pancreas morphogenesis, as well as there potential in generating beta cells. Furthermore, an emphasize is made on beta-cell regeneration and the determinants implicated.
由于 1 型糖尿病的患病率不断增加，以及实际治疗带来的并发症，需要建立替代疗法。为了弥补与 1 型糖尿病相关的β细胞缺乏，目前的研究集中在为移植目的生成产生胰岛素的β细胞的新策略上，包括干细胞或祖细胞的分化，以及非必需成熟细胞类型的转分化。然而，要成功地迫使任何细胞采用功能性β细胞命运或表型，需要更好地了解这些体内发生的分子机制。本综述总结了迄今为止已知的几个关键因子在胰腺形态发生过程中内分泌细胞谱系分化中的功能和相互作用，以及它们在生成β细胞中的潜力。此外，还强调了β细胞的再生和涉及的决定因素。
