Cell Differentiation Unit, Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.
Biol Chem. 2009 Oct;390(10):995-1001. doi: 10.1515/BC.2009.117.
Cell replacement therapy holds promises for treatment of patients suffering from diabetes mellitus. When determining the appropriate strategies to amplify the amount of transplantable beta-cells, sufficient knowledge of the developmental programs regulating beta-cell differentiation is crucial. Here, we describe the plasticity of the different pancreatic cell types in vivo and in vitro and their potential to serve as beta-cell progenitor.
细胞替代疗法为治疗糖尿病患者带来了希望。在确定扩增可移植β细胞数量的适当策略时，充分了解调节β细胞分化的发育程序至关重要。在这里，我们描述了不同胰腺细胞类型在体内和体外的可塑性及其作为β细胞祖细胞的潜力。
