载脂蛋白 1-192 基因多态性与冠心病的关系。
The relationship between paraoxonase1-192 polymorphism and activity with coronary artery disease.
机构信息
Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
出版信息
Clin Biochem. 2010 Apr;43(6):553-8. doi: 10.1016/j.clinbiochem.2009.12.015. Epub 2009 Dec 21.
OBJECTIVE
We tested the association between PON1 polymorphism, PON1 activity, oxidative susceptibility of LDL and coronary artery disease in Egyptians.
METHODS
PON1 polymorphism, serum PON1 activity, lipoprotein oxidation susceptibility and lipid profile were measured.
RESULTS
Levels of HDL and paraoxonase activity were significantly decreased in CAD patients compared to control group, and in patients with three vessels compared to those of single or two vessels disease. High-activity allele (R) has a more atherogenic lipid profile than for the low activity allele (Q). PON1 RR genotype has nine fold risks to develop CAD in Egyptians while those with PON1 QR genotype have four fold risks.
CONCLUSION
The PON1 activity is lower in subject with CAD and there is a significant relationship between activity of PON1 and the severity of coronary atherosclerosis. Also, we provide evidence of a significant association between R allele of the PON1 polymorphism and the development of coronary artery disease.
目的
我们在埃及人群中检测了 PON1 多态性、PON1 活性、LDL 氧化易感性与冠状动脉疾病之间的关系。
方法
测定了 PON1 多态性、血清 PON1 活性、脂蛋白氧化易感性和血脂谱。
结果
与对照组相比，冠心病患者的 HDL 水平和对氧磷酶活性显著降低，且三支病变患者比单支或两支病变患者降低更明显。与低活性等位基因（Q）相比，高活性等位基因（R）具有更易致动脉粥样硬化的血脂谱。PON1RR 基因型在埃及人中患 CAD 的风险增加九倍，而 PON1QR 基因型的风险增加四倍。
结论
冠心病患者的 PON1 活性较低，PON1 活性与冠状动脉粥样硬化严重程度之间存在显著关系。此外，我们还提供了 PON1 多态性的 R 等位基因与冠状动脉疾病发生之间存在显著相关性的证据。
Zotero 插件