对冠心病患者的对氧磷酶-1（PON-1）芳基酯酶活性水平的荟萃分析。
Paraoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis.
机构信息
Department of Translational Medicine and for Romagna, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
Department of Environmental and Prevention Sciences, University of Ferrara, Via Luigi Borsari 46, 44121, Italy.
出版信息
Dis Markers. 2022 Mar 10;2022:4264314. doi: 10.1155/2022/4264314. eCollection 2022.
AIM
To review and compare the PON-1 arylesterase activity between coronary artery disease (CAD) and non-CAD patients.
METHODS
Data were obtained by searching MEDLINE and Scopus for all investigations published between January 1, 2000 and March 1, 2021 comparing PON-1 arylesterase activity between CAD and controls.
RESULTS
Twenty studies, based on 5417 patients, met the inclusion criteria and were included in the analysis. A random effect model revealed that PON-1 arylesterase activity was significantly lower in the CAD group compared to controls (SMD = -0.587, 95%CI = -0.776 to -0.339, < 0.0001, = 92.3%). In CAD patients, the PON-1 arylesterase activity was significantly higher among CAD patients without diabetes mellitus (DM) compared to those with diabetes (SMD: 0.235, 95% CI: 0.014 to 0.456, = 0.03, = 0%).
CONCLUSIONS
PON-1 activity is significantly lower in CAD patients, and those without DM presented a significantly higher PON-1 arylesterase activity.
目的
回顾和比较冠心病（CAD）和非 CAD 患者的 PON-1 芳基酯酶活性。
方法
通过搜索 MEDLINE 和 Scopus 数据库，获取了 2000 年 1 月 1 日至 2021 年 3 月 1 日期间发表的所有比较 CAD 和对照组之间 PON-1 芳基酯酶活性的研究。
结果
符合纳入标准并纳入分析的有 20 项研究，共 5417 例患者。随机效应模型显示，CAD 组的 PON-1 芳基酯酶活性明显低于对照组（SMD=-0.587，95%CI=-0.776 至-0.339，<0.0001， =92.3%）。在 CAD 患者中，无糖尿病（DM）的 CAD 患者的 PON-1 芳基酯酶活性明显高于 DM 患者（SMD：0.235，95%CI：0.014 至 0.456， =0.03， =0%）。
结论
CAD 患者的 PON-1 活性明显降低，且无 DM 的患者的 PON-1 芳基酯酶活性明显升高。
Zotero 插件