Duke Global Health Institute, Duke University, Durham, NC 27708, USA.
J Pediatr Psychol. 2010 Sep;35(8):892-904. doi: 10.1093/jpepsy/jsp124. Epub 2009 Dec 21.
Children with sickle cell disease (SCD) exhibit poor somatic growth due to nutritional and metabolic effects, but potential relationships between growth and other areas of development are unclear. We examined whether growth is related to cognition and whether growth might be one marker of neurocognitive risk.
Sixty-four children with SCD and eighty-one demographically similar controls, ages 4 to 8 years, completed cognitive and anthropometric measures.
Height-for-age partially accounted for cognitive decrements related to SCD on all cognitive measures. Higher body-mass-index was a significant predictor of higher visual-motor and academic achievement scores in children with SCD, but not in controls.
In some children with SCD, especially those with HbSS and Hb Sbeta(0), low height-for-age may help to explain neurocognitive risk. Higher body-mass-index may be related to better cognitive outcomes in children with SCD. Nutrition deficits in SCD could explain the association between somatic growth and cognitive deficits.
镰状细胞病（SCD）患儿存在营养和代谢方面的问题，导致其生长不良，但目前尚不清楚生长与其他发育领域之间的潜在关系。我们研究了生长是否与认知有关，以及生长是否可能是神经认知风险的一个标志物。
64 名 SCD 患儿和 81 名年龄在 4 至 8 岁之间、具有相似人口统计学特征的对照组儿童完成了认知和人体测量学评估。
在所有认知评估中，身高与年龄之比部分解释了与 SCD 相关的认知能力下降。在 SCD 患儿中，较高的体重指数是视觉运动和学业成绩较高的显著预测指标，但在对照组中并非如此。
在一些 SCD 患儿中，尤其是 HbSS 和 Hb Sβ（0）的患儿，身高与年龄之比较低可能有助于解释神经认知风险。较高的体重指数可能与 SCD 患儿的认知结果更好有关。SCD 中的营养缺乏可能解释了躯体生长与认知缺陷之间的关联。
