Puffer Eve S, Schatz Jeffrey C, Roberts Carla W
University of South Carolina, USA Duke University, USA
University of South Carolina, USA.
J Health Psychol. 2016 Aug;21(8):1620-9. doi: 10.1177/1359105314559861. Epub 2014 Dec 8.
Children with sickle cell disease are at risk of cognitive deficits and somatic growth delays beginning in early childhood. We examined growth velocity from age 2 years (height and body mass index progression over time) and cognitive functioning in 46 children with sickle cell disease 4 to 8 years of age. Height-for-age velocity was not associated with cognitive outcomes. Higher body mass index velocity was associated with higher scores on global cognitive and visual-motor abilities but not processing resources or academic achievement. Body mass index progression over time may be a clinically useful indicator of neurocognitive risk in sickle cell disease, as it may reflect multiple sickle cell disease-related risk factors.
患有镰状细胞病的儿童从幼儿期开始就有认知缺陷和身体生长发育迟缓的风险。我们研究了46名4至8岁镰状细胞病患儿从2岁起的生长速度（身高和体重指数随时间的变化）和认知功能。年龄别身高增长速度与认知结果无关。较高的体重指数增长速度与整体认知和视觉运动能力得分较高有关，但与处理资源或学业成绩无关。体重指数随时间的变化可能是镰状细胞病神经认知风险的一个临床有用指标，因为它可能反映了多种与镰状细胞病相关的风险因素。
