Faculdade de Ciências Médicas, Instituto de Biologia do Exército, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Braz J Med Biol Res. 2010 Jan;43(1):120-3. doi: 10.1590/s0100-879x2009007500032. Epub 2009 Dec 18.
Serologic data on diseases that are preventable by vaccines are necessary to evaluate the success of immunization programs and to identify susceptible subgroups. In the present study, we determined serum IgG levels against diphtheria toxin of military and civilian blood donors (N = 75; 69.3% males and 30.7% females) aged 18-64 years, from the Brazilian Army Biology Institute, Rio de Janeiro, using a commercial diphtheria kit (Diphtheria IgG ELISA; IBL, Germany). Most (63%) unprotected military donors were from the older age group of 41 to 64 years. In contrast, the majority (71%) of young military donors (18 to 30 years) were fully protected. About half of the military donors aged 31 to 40 years were protected against diphtheria. Among the civilians, about 50% of persons aged 18 to 30 years and 31 to 40 years had protective antibody levels against diphtheria as also did 64% of individuals aged 41 to 64 years. All civilians had a similar antibody response (geometric mean = 0.55 IU/mL) independent of age group. Military donors aged 18-30 years had higher IgG levels (geometric mean = 0.82 IU/mL) than military donors of 41-64 years (geometric mean = 0.51 IU/mL; P > 0.05). In conclusion, the existence of a considerable proportion of susceptible adults supports the position that reliable data on the immune status of the population should be maintained routinely and emphasizes the importance of adequate immunization during adulthood.
血清学数据对于可通过疫苗预防的疾病是必要的，以评估免疫计划的成功，并确定易感亚组。在本研究中，我们使用商业白喉毒素试剂盒（Diphtheria IgG ELISA；IBL，德国）测定了来自巴西陆军生物学研究所的年龄在 18-64 岁的 75 名军事和民间献血者（69.3%为男性，30.7%为女性）血清中针对白喉毒素的 IgG 水平。大多数（63%）未受保护的军事献血者来自年龄较大的 41 至 64 岁组。相比之下，大多数（71%）年轻的军事献血者（18 至 30 岁）都受到了充分的保护。约一半年龄在 31 至 40 岁的军事献血者对白喉有保护作用。在平民中，约有 50%的 18 至 30 岁和 31 至 40 岁的人以及 64%的 41 至 64 岁的人对白喉具有保护性抗体水平。所有平民的抗体反应相似（几何均数=0.55IU/mL），与年龄组无关。18-30 岁的军事献血者的 IgG 水平（几何均数=0.82IU/mL）高于 41-64 岁的军事献血者（几何均数=0.51IU/mL；P>0.05）。总之，相当比例的成年人易受感染，这支持了应定期保持人群免疫状况可靠数据的观点，并强调了成年期充分免疫接种的重要性。
