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法国老年医学和老年病学会与法国心脏病学会关于老年人冠状动脉疾病管理的共识。

Consensus of the French Society of Gerontology and Geriatrics and the French Society of Cardiology for the management of coronary artery disease in older adults.

机构信息

Department of Geriatrics, université Paris-Descartes, hôpital Broca, 54-56, rue Pascal, 75013 Paris, France.

出版信息

Arch Cardiovasc Dis. 2009 Dec;102(12):829-45. doi: 10.1016/j.acvd.2009.09.004.

Abstract

Coronary heart disease is a common and serious condition in patients aged over 80 years. The presenting clinical symptoms are all the more atypical and the prognosis poorer when it occurs in patients with multiple comorbid diseases. The presence of comorbidities dictates the need for a standardized geriatric assessment to screen for the existence of underlying frailty. The available scientific data were obtained during studies that included few subjects aged over 80 years. These recommendations are therefore mainly extrapolated from results obtained in younger populations. The pharmacological management and revascularization strategy for coronary heart disease in octogenarians is basically the same as in younger subjects. Epidemiological studies all concur that available therapies are underutilized despite the fact that this population has a high cardiovascular risk. Specific precautions for use must be respected because of the comorbidities and age-related changes in pharmacokinetics or pharmacodynamics. Generally, the therapeutic strategy in coronary heart disease is based not on the patient's real age, but rather on an individual analysis taking into account the severity of the coronary disease, comorbidities, the risk of drug misadventures, patient life expectancy and quality of life.

摘要

冠心病是 80 岁以上患者中常见且严重的疾病。当患有多种合并症的患者发生冠心病时,其临床表现更为不典型,预后更差。合并症的存在需要进行标准化的老年评估,以筛查潜在的脆弱性。现有的科学数据是在包含少数 80 岁以上患者的研究中获得的。因此,这些建议主要是从较年轻人群中获得的结果推断而来。对于 80 岁以上患者的冠心病的药物治疗管理和血运重建策略与年轻患者基本相同。尽管这一人群具有较高的心血管风险,但流行病学研究都表明可用的治疗方法未得到充分利用。由于合并症和与年龄相关的药代动力学或药效学变化,必须遵守特定的使用注意事项。一般来说,冠心病的治疗策略不是基于患者的实际年龄,而是基于对冠状动脉疾病严重程度、合并症、药物意外风险、患者预期寿命和生活质量的个体分析。

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