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使用维甲酸泵治疗后的痤疮生活质量和患者满意度。

Acne quality of life and patient satisfaction following treatment with tretinoin pump.

作者信息

Fried Richard, Nighland Marge

机构信息

Yardley Dermatology Associates,Yardley, PA 19067, USA.

出版信息

J Drugs Dermatol. 2009 Dec;8(12):1080-5.

Abstract

Patient satisfaction and quality of life are important considerations when assessing products used to treat acne vulgaris, as these factors may affect treatment adherence and subsequent treatment outcomes. The objective of this analysis was to determine patient satisfaction and improvement in quality of life after treatment with tretinoin gel microsphere (TGM) in a pump dispenser. Assessments were made during a phase IV, prospective, 12-week, open-label, community-based trial in which 544 patients who were dissatisfied with their current acne treatments received TGM 0.04% or 0.1% in addition to < or = 2 concurrent non-retinoid acne therapies. At week 12, significant improvement was reported in both patient acne therapy satisfaction and in the overall mean Acne Quality of Life Index scale (P < 0.0001 versus baseline for both measures). The majority of patients (82.3%) rated the pump dispenser as an "excellent" or "very good" means of dispensing medication, and 86.0% rated their overall satisfaction with the pump treatment application as "very satisfied" or "extremely satisfied." The results of this study indicate that the use of TGM in a pump dispenser in patients with acne vulgaris is associated with significant increases in both quality of life and patient satisfaction.

摘要

在评估用于治疗寻常痤疮的产品时,患者满意度和生活质量是重要的考量因素,因为这些因素可能会影响治疗依从性及后续治疗效果。本分析的目的是确定在使用泵式 dispenser 剂型的维甲酸凝胶微球(TGM)治疗后患者的满意度及生活质量改善情况。评估是在一项IV期、前瞻性、为期12周的开放标签、基于社区的试验中进行的,该试验纳入了544名对当前痤疮治疗不满意的患者,这些患者除了同时接受≤2种非维甲酸类痤疮治疗外,还接受了0.04%或0.1%的TGM治疗。在第12周时,报告显示患者对痤疮治疗的满意度和痤疮生活质量指数总体平均得分均有显著改善(两项指标与基线相比P<0.0001)。大多数患者(82.3%)将泵式 dispenser 评为“优秀”或“非常好”的药物 dispensing 方式,86.0%的患者对泵式治疗应用的总体满意度评为“非常满意”或“极其满意”。本研究结果表明,在寻常痤疮患者中使用泵式 dispenser 剂型的TGM与生活质量和患者满意度的显著提高相关。

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