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Dermatol Ther (Heidelb). 2014 Jun;4(1):61-70. doi: 10.1007/s13555-014-0054-1. Epub 2014 Jun 12.
Acne is a chronic inflammatory disease. Key to a patient's success on fixed-dose adapalene-benzoyl peroxide (BPO) gel is ensuring adherence. Use of a pump system to deliver a pre-measured amount of gel with each pressure enables application of a more consistent dose vs. the tube, which should improve adherence. In the present study, we evaluate patient preference for two different containers for dispensing adapalene-BPO gel.
In this 15-day, open-label study, 300 subjects were asked to treat their acne using fixed-dose adapalene 0.1%-BPO 2.5% gel dispensed in either a tube or a pump once-daily for up to 7 days. At week 1, subjects switched to the alternative packaging design for the same timeframe. At the end of the treatment period, subjects were asked to complete a subject preference survey.
Among subjects completing the survey (n = 291), 79.0% (n = 230) preferred the pump for dispensing adapalene-BPO gel and 21.0% (n = 61) preferred the tube (p < 0.001). The top three characteristics of the pump were that it was easy to use (89.0%; n = 259/291), clean (73.2%; n = 213/291) and convenient (69.4%; n = 202/291). When asked to rate their experience with using the pump, 91.8% (n = 267/291; p < 0.001) of subjects reported being satisfied on a self-assessment scale. The majority of subjects stated they would tell their doctor about their preference for the pump next time adapalene-BPO gel was prescribed (76.6%; n = 223/291; p < 0.001) and would prefer the pump if both containers cost the same amount (80.1%; n = 233/291; p < 0.001).
Patients prefer using a pump instead of a tube to dispense adapalene-BPO gel. This delivery mechanism helps to ensure consistent application and thus may improve patient adherence to the prescribed acne treatment regimen.
痤疮是一种慢性炎症性疾病。确保患者坚持使用固定剂量的阿达帕林-过氧化苯甲酰（BPO）凝胶的关键是确保其依从性。使用泵系统每次按压输送预定量的凝胶可以实现更一致的剂量，与管相比，这应该可以提高依从性。在本研究中，我们评估了两种不同的容器用于分配阿达帕林-BPO 凝胶的患者偏好。
在这项为期 15 天的开放性研究中，300 名患者被要求使用固定剂量的阿达帕林 0.1%-BPO 2.5%凝胶治疗痤疮，每天一次，持续 7 天，这些凝胶分别装在管或泵中。在第 1 周，患者切换到另一种包装设计，持续同样的时间。在治疗结束时，患者被要求完成一项患者偏好调查。
在完成调查的患者中（n=291），79.0%（n=230）更喜欢使用泵分配阿达帕林-BPO 凝胶，21.0%（n=61）更喜欢使用管（p<0.001）。泵的前三个特点是易于使用（89.0%；n=259/291）、清洁（73.2%；n=213/291）和方便（69.4%；n=202/291）。当被问及他们使用泵的体验时，91.8%（n=267/291；p<0.001）的患者在自我评估量表上表示满意。大多数患者表示，下次开阿达帕林-BPO 凝胶处方时，他们会将对泵的偏好告诉医生（76.6%；n=223/291；p<0.001），并且如果两种容器的价格相同，他们会更喜欢泵（80.1%；n=233/291；p<0.001）。
患者更喜欢使用泵而不是管来分配阿达帕林-BPO 凝胶。这种输送机制有助于确保一致的应用，从而可能提高患者对规定的痤疮治疗方案的依从性。
