Rakhimov M M, Almatov K t
Biokhimiia. 1977 Oct;42(10):1852-63.
A character of rat liver mitochondria degradation after the heat treatment of animals is studied. It is found that mitochondria under the effect of elevated temperature do not considerably change their functional characteristics and thus they are capable to provide the normal rate of ATP synthesis, the rate of succinate oxidation being slightly increased. At the same time the heating caused the degradation of mitochondria which results in the decrease of their thermostability, in the increased susceptibility to lytic effect of trypsin and phospholipase D, and in the activation of succinate dehydrogenase and cytochrome c oxidase. The mitochondria degradation is due to the formation of "latent impairments" in the structure of mitochondria.
研究了动物热处理后大鼠肝脏线粒体降解的特征。发现高温作用下的线粒体功能特性没有显著变化，因此它们能够维持正常的ATP合成速率，琥珀酸氧化速率略有增加。同时，加热导致线粒体降解，这使其热稳定性降低，对胰蛋白酶和磷脂酶D的裂解作用敏感性增加，琥珀酸脱氢酶和细胞色素c氧化酶被激活。线粒体降解是由于线粒体结构中形成了“潜在损伤”。
