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环境温度升高对大鼠肝脏线粒体氧化过程的影响。

Influence of increased environmental temperature on oxidation processes in rat liver mitochondria.

作者信息

Skonieczna M, Kruszewska J, Nowak J, Bicz W

出版信息

Acta Physiol Pol. 1986 Jul-Aug;37(4-5):157-67.

PMID:3035873
Abstract

Exposure of rats to elevated temperature of 28 degrees C or 35 degrees C for 3 days six hours daily resulted in a decreased rate of oxidation with succinate or glutamate + malate as substrates, by the mitochondria of liver. The higher decrease was observed in environment temperature of 35 degrees C. There was no change in ADP/O ratio. The activities of NADH: cytochrome c reductase and cytochrome oxidase were stimulated but activities of succinate dehydrogenase and succinate cytochrome reductase were decreased.

摘要

每天6小时,连续3天将大鼠暴露于28摄氏度或35摄氏度的高温环境中,导致以琥珀酸或谷氨酸+苹果酸为底物时,肝脏线粒体的氧化速率降低。在35摄氏度的环境温度下观察到的降低幅度更大。ADP/O比值没有变化。NADH:细胞色素c还原酶和细胞色素氧化酶的活性受到刺激,但琥珀酸脱氢酶和琥珀酸细胞色素还原酶的活性降低。

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