Department of Neurology and Epileptology, Medical Center for Postgraduate Education, Warsaw, Poland.
Acta Neurol Scand. 2010 Apr;121(4):230-6. doi: 10.1111/j.1600-0404.2009.01185.x. Epub 2009 Dec 17.
To investigate the role of leptin, ghrelin, GH and IGF-1 in energy balance disturbances in Parkinson's disease (PD).
Thirty-nine patients were included: 11 PD patients with unintentional weight loss, 16 PD patients without weight loss and 12 controls. UPDRS, MMSE, MADRS, appetite scale, BMI, adipose tissue content, plasma leptin and active ghrelin concentrations and serum GH, IGF-1, TSH, T3 and T4, concentrations were evaluated.
A lower plasma leptin concentration and a higher serum IGF-1 concentration were found in PD patients with weight loss. BMI and the content of adipose tissue were positively correlated with leptin concentration in all PD patients. Paradoxically, the lower BMI was, the lower plasma active ghrelin concentration was in PD patients with the weight loss.
These findings confirm that changes of plasma leptin concentration occur in PD patients with loss of weight.
探讨瘦素、胃饥饿素、GH 和 IGF-1 在帕金森病（PD）能量平衡紊乱中的作用。
共纳入 39 例患者：11 例 PD 伴非故意体重减轻患者、16 例 PD 无体重减轻患者和 12 例对照。评估 UPDRS、MMSE、MADRS、食欲量表、BMI、脂肪组织含量、血浆瘦素和活性胃饥饿素浓度以及血清 GH、IGF-1、TSH、T3 和 T4 浓度。
体重减轻的 PD 患者血浆瘦素浓度较低，血清 IGF-1 浓度较高。在所有 PD 患者中，BMI 和脂肪组织含量与瘦素浓度呈正相关。矛盾的是，体重减轻的 PD 患者的 BMI 越低，血浆活性胃饥饿素浓度越低。
这些发现证实，体重减轻的 PD 患者的血浆瘦素浓度发生变化。
