Erkens A M, Kuijpers R J, Knottnerus J A
Rijksuniversiteit Limburg, vakgroep Huisartsgeneeskunde, Maastricht.
Ned Tijdschr Geneeskd. 1991 Feb 2;135(5):171-4.
Comparison of the effectiveness of liquid nitrogen and of cryotherapy by means of the Histofreezer in the treatment of hand warts.
Randomized therapeutic trial.
Six general practices in Limburg, The Netherlands.
Of the patients 43 (with 83 warts) were treated with nitrogen (if necessary twice) and 50 (with 108 warts) with the Histofreezer (if necessary 4 times), with a final control visit after 2.5 months. After a training session, the general practitioners performed the treatments and the observations. In these groups, 7 patients (with 18 warts) and 10 patients (with 20 warts) respectively did not fully comply with the protocol. At the start the number of warts per patient, their size, protruberance and localization were registered. Statistical analysis was performed by chi 2 test (unpaired case) in an intention to treat approach and of compliers only.
Disappearance of warts, pain (on a 3-point scale), wounds, depigmentation. Non-compliers were asked by telephone if their warts had been cured.
Of all patients 58% was cured by liquid nitrogen and 28% by Histofreezer (p = 0.01). Among the compliers these percentages were 67% and 35% of the patients (p = 0.01) and 66% and 49% of the warts (p = 0.08). The treatments were about equally effective in dorsal non protuberant and small (less than 5 mm) warts, and among young (less than 20 years) patients.
The overall results of liquid nitrogen were better. The Histofreezer seems to be attractive in certain cases (e.g. children), but this should be the subject of further study.
比较液氮和使用组织冷冻器进行冷冻疗法治疗手部疣的有效性。
随机治疗试验。
荷兰林堡的六个普通诊所。
43名患者（共83个疣）接受液氮治疗（必要时进行两次），50名患者（共108个疣）接受组织冷冻器治疗（必要时进行4次），2.5个月后进行最终对照访视。经过培训后，全科医生进行治疗和观察。在这些组中，分别有7名患者（共18个疣）和10名患者（共20个疣）未完全遵守方案。开始时记录每位患者的疣数量、大小、突出情况和位置。采用意向性治疗方法和仅针对依从者进行卡方检验（非配对病例）进行统计分析。
疣消失、疼痛（采用3分制）、伤口、色素脱失。通过电话询问未依从者其疣是否已治愈。
所有患者中，58%通过液氮治愈，28%通过组织冷冻器治愈（p = 0.01）。在依从者中，这些百分比分别为患者的67%和35%（p = 0.01）以及疣的66%和49%（p = 0.08）。在背部非突出且较小（小于5毫米）的疣以及年轻（小于20岁）患者中，两种治疗方法效果大致相同。
液氮的总体效果更好。组织冷冻器在某些情况下（如儿童）似乎具有吸引力，但这应作为进一步研究的主题。
