Khaled Aida, Ben Romdhane Salma, Kharfi Monia, Zeglaoui Faten, Fazaa Becima, Kamoun Mohamed Ridha
Service de Dermatologie, Hôpital Charles Nicolle, Tunis.
Tunis Med. 2009 Oct;87(10):690-2.
Cryotherapy with liquid nitrogen is the most widely used method to treat hand and feet warts. Therapeutic response to this method depends on many factors related to warts and to the patient. The aim of this study is to determine factors influencing therapeutic response of warts to cryotherapy by liquid nitrogen.
It was a prospective transversal study including 100 patients with warts of the hands and/or feet treated by cryotherapy with liquid nitrogen (cotton wool bud) and referred to Dermatology Department of Charles Nicolle Hospital of Tunis. Demographic data, so as characteristics of warts were recorded. Patients received one treatment/week with a maximum of 4 sessions. Patients whose warts were seen to be resolved were classified as cured. Cure-predictive factors were studied with a multi varied study with logistic regression.
Of the 100 patients (56 females/44 males, Mean age: 22 years), ten were withdrawn. In 89 patients, warts were present on hands, whereas 23 had warts on feet and 12 had warts on both hands and feet. The mean number of warts per patient was 7. The total cure rate was of 64.4% and was more elevated in hands compared to feet (70.8% versus 10.5%). There was no difference between mean ages of cured group and not cured one (22.2 years versus 21 years). The mean duration of warts in cured patients was lower than that of not cured patients. The mean number of warts before treatment was 4.3 in cured patients and 12.3 warts in not cured patients. The mean number of treatments was 2.3 in cured patients and 4 treatments in not cured patients. The difference between these factors into cured and not cured groups was statistically significant in uni-varied study but not significant in multi-varied one.
The effectiveness of liquid nitrogen used by traditional method in the treatment of hand and feet warts seems to depend on multiple factors: wart's duration, number of warts and number of treatments. These factors depend on each other.
液氮冷冻疗法是治疗手足疣最常用的方法。该方法的治疗效果取决于许多与疣体及患者相关的因素。本研究的目的是确定影响液氮冷冻疗法治疗疣疗效的因素。
这是一项前瞻性横断面研究，纳入了100例接受液氮（棉棒）冷冻治疗的手足疣患者，这些患者均转诊至突尼斯查尔斯·尼科勒医院皮肤科。记录了人口统计学数据以及疣体特征。患者每周接受一次治疗，最多4次。疣体被视为消退的患者被分类为治愈。采用多变量逻辑回归研究治愈预测因素。
100例患者（56例女性/44例男性，平均年龄：22岁）中，10例退出研究。89例患者手部有疣体，23例足部有疣体，12例手足均有疣体。每位患者疣体的平均数量为7个。总治愈率为64.4%，手部的治愈率高于足部（70.8%对10.5%）。治愈组和未治愈组的平均年龄无差异（22.2岁对21岁）。治愈患者疣体的平均病程低于未治愈患者。治愈患者治疗前疣体的平均数量为4.3个，未治愈患者为12.3个。治愈患者的平均治疗次数为2.3次，未治愈患者为4次。在单变量研究中，这些因素在治愈组和未治愈组之间的差异具有统计学意义，但在多变量研究中不显著。
传统方法使用液氮治疗手足疣的有效性似乎取决于多个因素：疣体病程、疣体数量和治疗次数。这些因素相互影响。
