Laboratoire de Physiologie Animale, Université Libre de Bruxelles, Gosselies, Belgium.
Cancer Res. 2010 Jan 1;70(1):8-11. doi: 10.1158/0008-5472.CAN-09-2465. Epub 2009 Dec 22.
Beyond its well-described role in cellular metabolism, intracellular nicotinamide adenine dinucleotide (NAD) levels have been shown to affect the enzymatic activity of a series of NAD-dependent enzymes, influencing biological responses such as cell survival and inflammation. Nicotinamide phosphoribosyl transferase activity has been shown to be essential for maintaining adequate intracellular NAD levels, suggesting that this enzyme may in fact play a central role in modulating the activity of a wide range of NAD-dependent enzymes. Several recent observations concur with this hypothesis and suggest that by regulating NAD availability, Nampt is able to control both cell viability and the inflammatory response. Nampt may thus represent a novel pharmacological target with valuable anti-inflammatory and antitumor properties.
除了在细胞代谢中作用明确之外，细胞内烟酰胺腺嘌呤二核苷酸（NAD）水平也被证明会影响一系列 NAD 依赖性酶的酶活性，从而影响细胞存活和炎症等生物学反应。烟酰胺磷酸核糖基转移酶活性对于维持细胞内足够的 NAD 水平至关重要，这表明该酶实际上可能在调节广泛的 NAD 依赖性酶的活性方面发挥核心作用。最近的一些观察结果与这一假设一致，并表明通过调节 NAD 的可用性，Nampt 能够控制细胞活力和炎症反应。因此，Nampt 可能代表具有有价值的抗炎和抗肿瘤特性的新型药理学靶标。
