Garten Antje, Petzold Stefanie, Schuster Susanne, Körner Antje, Kratzsch Jürgen, Kiess Wieland
University of Leipzig, Hospital for Children and Adolescents, Liebigstr. 20a, 04103, Leipzig, Germany.
Handb Exp Pharmacol. 2011(203):147-64. doi: 10.1007/978-3-642-17214-4_7.
Nicotinamide phosphoribosyltransferase Nicotinamide phosphoribosyltransferase (Nampt Nampt ) is a key nicotinamide adenine dinucleotide (NAD) NAD biosynthetic enzyme in mammals, converting nicotinamide nicotinamide into nicotinamide mononucleotide nicotinamide mononucleotide (NMN NMN ), an NAD intermediate. First identified in humans as a cytokine cytokine pre-B-cell colony enhancing factor pre-B cell colony enhancing factor (PBEF PBEF ) and subsequently described as an insulin-mimetic hormone visfatin visfatin , Nampt has recently excited the scientific interest of researchers from diverse fields, including NAD biology, metabolic regulation, and inflammation. As an NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins sirtuins and influences a variety of metabolic and stress responses. Nampt plays an important role in the regulation of insulin secretion insulin secretion in pancreatic β-cells. Nampt also functions as an immunomodulatory cytokine cytokine and is involved in the regulation of inflammatory responses. This chapter summarizes the various functional aspects of Nampt and discusses its potential roles in diseases, with special focus on type 2 diabetes mellitus (T2DM).
烟酰胺磷酸核糖转移酶 烟酰胺磷酸核糖转移酶（Nampt）是哺乳动物中烟酰胺腺嘌呤二核苷酸（NAD）生物合成的关键酶，可将烟酰胺转化为烟酰胺单核苷酸（NMN），NMN是NAD的一种中间体。Nampt最初在人类中被鉴定为细胞因子前B细胞集落增强因子（PBEF），随后被描述为一种胰岛素模拟激素内脂素，最近它激发了包括NAD生物学、代谢调节和炎症等不同领域研究人员的科学兴趣。作为一种NAD生物合成酶，Nampt调节诸如去乙酰化酶等消耗NAD的酶的活性，并影响多种代谢和应激反应。Nampt在胰腺β细胞胰岛素分泌的调节中起重要作用。Nampt还作为一种免疫调节细胞因子发挥作用，并参与炎症反应的调节。本章总结了Nampt的各种功能方面，并讨论了其在疾病中的潜在作用，特别关注2型糖尿病（T2DM）。
