Department of Radiology, Tenon Hospital, and Pierre et Marie Curie University, 4 Rue de la Chine, 75020 Paris, France.
AJR Am J Roentgenol. 2010 Jan;194(1):W104-10. doi: 10.2214/AJR.09.2379.
The purpose of this study was a preliminary evaluation of the use of ethylene vinyl alcohol copolymer to treat patients with hemoptysis of systemic arterial origin.
We reviewed the cases of 15 consecutively registered patients (10 men, five women; mean age, 53.7 years) who underwent endovascular administration of ethylene vinyl alcohol copolymer in the management of hemoptysis. The indications, immediate control of hemoptysis, and clinical tolerability were analyzed.
The indications for embolization were mainly early recurrence of hemoptysis with reperfusion of systemic arteries in seven cases; unstable microcatheter in two cases; large ectopic bronchial artery in two cases; and, in one case each, bronchial arterial bleeding through a small anastomotic network, aneurysm of the left internal thoracic artery in a patient with invasive aspergillosis, a potentially risky connection between the bronchial and right coronary arteries, and occlusion of a systemic artery due to Pryce type 1 intralobar lung sequestration. Hemoptysis was controlled in all but one case and did not recur in the other 14 cases. The injection procedure was well tolerated.
Ethylene vinyl alcohol copolymer embolization for hemoptysis of systemic arterial origin is feasible. The agent seems beneficial in the care of patients with recurrent hemoptysis after previous bronchial arterial embolization, patients who would be at high risk during embolization with microparticles, and patients who need embolization of large systemic arteries through small-caliber anastomoses.
本研究旨在初步评估使用乙烯-乙烯醇共聚物治疗源于体循环动脉的咯血患者。
我们回顾了 15 例连续登记的患者(10 例男性,5 例女性;平均年龄 53.7 岁)的病例,这些患者接受了乙烯-乙烯醇共聚物的血管内给药治疗以控制咯血。分析了栓塞的适应证、咯血的即刻控制和临床耐受性。
栓塞的适应证主要为 7 例患者为体循环动脉再灌注后的早期复发性咯血;2 例为不稳定微导管;2 例为异位支气管动脉较大;1 例为支气管动脉通过小吻合网出血;1 例为侵袭性曲霉菌感染患者的左内乳动脉动脉瘤;1 例为潜在风险的支气管和右冠状动脉之间的连接;1 例为因 Pryce 1 型肺隔离症导致的体循环动脉闭塞。除 1 例外,所有患者的咯血均得到控制,且在其余 14 例患者中未再复发。注射过程耐受良好。
乙烯-乙烯醇共聚物栓塞治疗源于体循环动脉的咯血是可行的。对于先前支气管动脉栓塞后复发性咯血的患者、需要通过小口径吻合进行大口径体循环动脉栓塞的患者,该药物似乎有益。