黄嘌呤氧化酶抑制在预防和治疗心脑血管疾病中的潜力。
The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease.
作者信息
Higgins Peter, Dawson Jesse, Walters Matthew
机构信息
Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G11 6NT, UK.
出版信息
Cardiovasc Psychiatry Neurol. 2009;2009:282059. doi: 10.1155/2009/282059. Epub 2009 Nov 4.
Abstract
There is a now a wealth of epidemiological, animal, and clinical data to suggest the benefits of uric acid reduction and hxanthine oxidase inhibition in prevention of vascular disease. This review discusses the available epidemiological, preclinical, and clinical data and considers arguments for and against a role for serum uric acid in common cardiovascular disorders. It concludes that large scale trials with clinical endpoints are justified to address this important question and to define whether use of drugs such as allopurinol should be a routine part of preventative strategies.
摘要
目前有大量的流行病学、动物实验和临床数据表明，降低尿酸水平和抑制黄嘌呤氧化酶对预防血管疾病有益。本文综述了现有的流行病学、临床前和临床数据，并探讨了支持和反对血清尿酸在常见心血管疾病中作用的观点。结论是，进行以临床终点为指标的大规模试验是合理的，以解决这一重要问题，并确定使用如别嘌呤醇等药物是否应成为预防策略的常规组成部分。
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