Nichols Charles D
Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA 70112, USA.
Cardiovasc Psychiatry Neurol. 2009;2009:475108. doi: 10.1155/2009/475108. Epub 2009 Oct 13.
There are high levels of comorbidity between neuropsychiatric and cardiovascular disorders. A key molecule central to both cognitive and cardiovascular function is the molecule serotonin. In the brain, serotonin modulates neuronal activity and is actively involved in mediating many cognitive functions and behaviors. In the periphery, serotonin is involved in vasoconstriction, inflammation, and cell growth, among other processes. It is hypothesized that one component of the serotonin system, the 5-HT(2A) receptor, is a common and contributing factor underlying aspects of the comorbidity between neuropsychiatric and cardiovascular disorders. Within the brain this receptor participates in processes such as cognition and working memory, been implicated in effective disorders such as schizophrenia, and mediate the primary effects of hallucinogenic drugs. In the periphery, 5-HT(2A) receptors have been linked to vasoconstriction and hypertension, and to inflammatory processes that can lead to atherosclerosis.
神经精神疾病和心血管疾病之间存在高度共病现象。血清素是认知和心血管功能的关键核心分子。在大脑中，血清素调节神经元活动，并积极参与介导许多认知功能和行为。在周围组织中，血清素参与血管收缩、炎症和细胞生长等过程。据推测，血清素系统的一个组成部分，即5-HT(2A)受体，是神经精神疾病和心血管疾病共病的一个共同且起作用的因素。在大脑中，该受体参与认知和工作记忆等过程，与精神分裂症等精神疾病有关，并介导致幻药物的主要作用。在周围组织中，5-HT(2A)受体与血管收缩、高血压以及可导致动脉粥样硬化的炎症过程有关。
