血清素5-HT(2A)受体功能作为神经精神疾病和心血管疾病的一个促成因素。
Serotonin 5-HT(2A) Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases.
作者信息
Nichols Charles D
机构信息
Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA 70112, USA.
出版信息
Cardiovasc Psychiatry Neurol. 2009;2009:475108. doi: 10.1155/2009/475108. Epub 2009 Oct 13.
Abstract
There are high levels of comorbidity between neuropsychiatric and cardiovascular disorders. A key molecule central to both cognitive and cardiovascular function is the molecule serotonin. In the brain, serotonin modulates neuronal activity and is actively involved in mediating many cognitive functions and behaviors. In the periphery, serotonin is involved in vasoconstriction, inflammation, and cell growth, among other processes. It is hypothesized that one component of the serotonin system, the 5-HT(2A) receptor, is a common and contributing factor underlying aspects of the comorbidity between neuropsychiatric and cardiovascular disorders. Within the brain this receptor participates in processes such as cognition and working memory, been implicated in effective disorders such as schizophrenia, and mediate the primary effects of hallucinogenic drugs. In the periphery, 5-HT(2A) receptors have been linked to vasoconstriction and hypertension, and to inflammatory processes that can lead to atherosclerosis.
摘要
神经精神疾病和心血管疾病之间存在高度共病现象。血清素是认知和心血管功能的关键核心分子。在大脑中，血清素调节神经元活动，并积极参与介导许多认知功能和行为。在周围组织中，血清素参与血管收缩、炎症和细胞生长等过程。据推测，血清素系统的一个组成部分，即5-HT(2A)受体，是神经精神疾病和心血管疾病共病的一个共同且起作用的因素。在大脑中，该受体参与认知和工作记忆等过程，与精神分裂症等精神疾病有关，并介导致幻药物的主要作用。在周围组织中，5-HT(2A)受体与血管收缩、高血压以及可导致动脉粥样硬化的炎症过程有关。
相似文献
1
Serotonin 5-HT(2A) Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases.血清素5-HT(2A)受体功能作为神经精神疾病和心血管疾病的一个促成因素。
Cardiovasc Psychiatry Neurol. 2009;2009:475108. doi: 10.1155/2009/475108. Epub 2009 Oct 13.
2
Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency.血清素5-羟色胺（2A）受体激活以非凡的效力抑制肿瘤坏死因子-α诱导的炎症。
J Pharmacol Exp Ther. 2008 Nov;327(2):316-23. doi: 10.1124/jpet.108.143461. Epub 2008 Aug 15.
3
Cardiovascular responses produced by 5-hydroxytriptamine:a pharmacological update on the receptors/mechanisms involved and therapeutic implications.5-羟色胺引起的心血管反应：关于相关受体/机制及治疗意义的药理学最新进展
Naunyn Schmiedebergs Arch Pharmacol. 2007 Oct;376(1-2):45-63. doi: 10.1007/s00210-007-0179-1. Epub 2007 Aug 17.
4
(1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity.(1R, 3S)-(-)-反式-PAT：一种新型的具有5-HT2A和5-HT2B受体反向激动剂/拮抗剂活性的全效血清素5-HT2C受体激动剂。
Eur J Pharmacol. 2009 Aug 1;615(1-3):1-9. doi: 10.1016/j.ejphar.2009.04.035. Epub 2009 May 3.
5
Cognitive dysfunction in neuropsychiatric disorders: selected serotonin receptor subtypes as therapeutic targets.神经精神疾病中的认知功能障碍：选定的血清素受体亚型作为治疗靶点。
Behav Brain Res. 2008 Dec 16;195(1):30-8. doi: 10.1016/j.bbr.2007.12.006. Epub 2008 Feb 1.
6
Chronic treatment of hydroxytryptamine type 2a receptor antagonist sarpogrelate hydrochloride modulates the vasoreactivity of serotonin in experimental rabbit vein grafts.对2a型羟色胺受体拮抗剂盐酸沙格雷酯进行长期治疗可调节实验性兔静脉移植物中血清素的血管反应性。
J Vasc Surg. 2009 Sep;50(3):617-25. doi: 10.1016/j.jvs.2009.05.065.
7
A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex.丘脑皮质传入神经在大鼠新皮质中5-羟色胺能致幻剂受体功能中的主要作用。
Neuroscience. 2001;105(2):379-92. doi: 10.1016/s0306-4522(01)00199-3.
8
Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of n-methyl-D-aspartate receptor channels in pyramidal neurons of prefrontal cortex.5-HT2A/C受体的激活可抵消前额叶皮层锥体神经元中5-HT1A对N-甲基-D-天冬氨酸受体通道的调节作用。
J Biol Chem. 2008 Jun 20;283(25):17194-204. doi: 10.1074/jbc.M801713200. Epub 2008 Apr 28.
9
Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice.条件性脑源性神经营养因子敲除小鼠中 5-HT2A 介导的行为以及 5-HT2A 和 5-HT1A 受体结合和表达的变化。
Neuroscience. 2010 Sep 1;169(3):1007-16. doi: 10.1016/j.neuroscience.2010.05.054. Epub 2010 Jun 1.
10
Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists.5-羟色胺2A（5-HT(2A)）受体激动剂和拮抗剂的反常转运与调节
Brain Res Bull. 2001 Nov 15;56(5):441-51. doi: 10.1016/s0361-9230(01)00623-2.
引用本文的文献
1
Modulatory effects of noradrenergic and serotonergic signaling pathway on neurovascular coupling.去甲肾上腺素能和血清素能信号通路对神经血管耦合的调节作用。
Commun Biol. 2024 Mar 8;7(1):287. doi: 10.1038/s42003-024-05996-y.
2
On the construction of LIECE models for the serotonin receptor 5-HT[Formula: see text]R.构建血清素受体 5-HT[Formula: see text]R 的 LIECE 模型。
J Comput Aided Mol Des. 2023 Jul;37(7):313-323. doi: 10.1007/s10822-023-00507-3. Epub 2023 Jun 14.
3
Psychedelics and Anti-inflammatory Activity in Animal Models.致幻剂与动物模型中的抗炎活性。
Curr Top Behav Neurosci. 2022;56:229-245. doi: 10.1007/7854_2022_367.
4
Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors.裸盖菇素，一种天然存在的吲哚胺化合物，可能有助于预防自杀行为。
Pharmaceuticals (Basel). 2021 Nov 24;14(12):1213. doi: 10.3390/ph14121213.
5
Protective Role of Sarpogrelate in Combination with Bromocriptine and Cabergoline for Treatment of Diabetes in Alloxan-induced Diabetic Rats.沙格雷酯联合溴隐亭和卡麦角林对四氧嘧啶诱导的糖尿病大鼠糖尿病的治疗保护作用
Curr Ther Res Clin Exp. 2021 Oct 12;95:100647. doi: 10.1016/j.curtheres.2021.100647. eCollection 2021.
6
Therapeutic activity of sarpogrelate and dopamine D receptor agonists on cardiovascular and renal systems in rats with alloxan-induced diabetes.阿朴吗啡及多巴胺 D 受体激动剂对四氧嘧啶诱导糖尿病大鼠心血管和肾脏系统的治疗作用。
BMC Pharmacol Toxicol. 2021 Oct 26;22(1):64. doi: 10.1186/s40360-021-00526-6.
7
Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway.自闭症和阿尔茨海默病小鼠模型的蛋白质组学研究揭示了 mTOR 信号通路的常见改变。
Transl Psychiatry. 2021 Sep 17;11(1):480. doi: 10.1038/s41398-021-01578-2.
8
Associations between lifetime classic psychedelic use and cardiometabolic diseases.一生中使用经典迷幻药物与心血管代谢疾病之间的关联。
Sci Rep. 2021 Jul 13;11(1):14427. doi: 10.1038/s41598-021-93787-4.
9
Structure-Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore.致幻剂在哮喘大鼠模型中的构效关系分析揭示了抗炎药效基团。
ACS Pharmacol Transl Sci. 2020 Aug 13;4(2):488-502. doi: 10.1021/acsptsci.0c00063. eCollection 2021 Apr 9.
10
Associations between lifetime classic psychedelic use and markers of physical health.一生中经典致幻剂使用与身体健康标志物之间的关联。
J Psychopharmacol. 2021 Apr;35(4):447-452. doi: 10.1177/0269881121996863. Epub 2021 Mar 9.
本文引用的文献
1
Comorbidity between depression and cardiovascular disease.抑郁症与心血管疾病之间的共病现象。
Int Angiol. 2009 Apr;28(2):92-9.
2
Lifestyles and cardiovascular risk in individuals with functional psychoses.功能性精神病患者的生活方式与心血管风险。
Perspect Psychiatr Care. 2009 Apr;45(2):87-99. doi: 10.1111/j.1744-6163.2009.00202.x.
3
The metabolic syndrome and schizophrenia.代谢综合征与精神分裂症。
Acta Psychiatr Scand. 2009 Jan;119(1):4-14. doi: 10.1111/j.1600-0447.2008.01317.x.
4
Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A.重度抑郁症患者死后前额叶皮质中5-HT 2A受体升高与蛋白激酶A活性降低有关。
Neuroscience. 2009 Feb 18;158(4):1406-15. doi: 10.1016/j.neuroscience.2008.11.036. Epub 2008 Dec 3.
5
Serotonin research: contributions to understanding psychoses.血清素研究：对理解精神病的贡献。
Trends Pharmacol Sci. 2008 Sep;29(9):445-53. doi: 10.1016/j.tips.2008.06.006.
6
HPA axis hyperactivity and cardiovascular mortality in mood disorder inpatients.心境障碍住院患者的下丘脑-垂体-肾上腺（HPA）轴功能亢进与心血管死亡率
J Affect Disord. 2009 Jul;116(1-2):88-92. doi: 10.1016/j.jad.2008.10.025. Epub 2008 Dec 2.
7
The beginning of a fantastic, unanswered question: is 5-HT involved in systemic hypertension?一个奇妙且尚无答案的问题由此开篇：5-羟色胺与系统性高血压有关吗？
Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H915-H916. doi: 10.1152/classicessays.zh4-8503.2008.
8
In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems.非典型抗精神病药物对5-羟色胺能和多巴胺能系统的体内作用。
Prog Brain Res. 2008;172:177-97. doi: 10.1016/S0079-6123(08)00909-6.
9
Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency.血清素5-羟色胺（2A）受体激活以非凡的效力抑制肿瘤坏死因子-α诱导的炎症。
J Pharmacol Exp Ther. 2008 Nov;327(2):316-23. doi: 10.1124/jpet.108.143461. Epub 2008 Aug 15.
10
Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin.酮色林对人醚-去极化相关基因钾通道的阻断作用。
Sheng Li Xue Bao. 2008 Aug 25;60(4):525-34.
Zotero 插件