Faculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Norway.
Gastroenterol Res Pract. 2009;2009:285830. doi: 10.1155/2009/285830. Epub 2009 Dec 15.
Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992-2000 was investigated and was compared to a material of 219 colon cancers operated on at Akershus University Hospital during the years 1988, 1990 and 1997-2000. There were highly significant differences between the rectal and the colon cancers in the protein expression of cyclin D1, cyclin D3, cyclin E, nuclear beta-catenin, and c-Myc and in gene amplification of cyclin A2, cyclin B1, cyclin D1, and cyclin E. Gene amplification and protein expression in the rectal cancers correlated significantly for the cyclins B1, D3, and E. A statistically significant relation was observed between overexpression of cyclin A2 and local relapse of rectal carcinomas, as higher expression of cyclin A2 was associated with lower local recurrence rate.
直肠和结肠的腺癌在癌症发展的细胞生物学基础方面可能有所不同。对阿克什胡斯大学医院 1992-2000 年间手术切除的 246 例直肠癌标本进行了研究，并与阿克什胡斯大学医院 1988 年、1990 年和 1997-2000 年间手术切除的 219 例结肠癌标本进行了比较。在 cyclin D1、cyclin D3、cyclin E、核 β-catenin 和 c-Myc 的蛋白表达以及 cyclin A2、cyclin B1、cyclin D1 和 cyclin E 的基因扩增方面，直肠癌和结肠癌之间存在显著差异。直肠癌中 cyclin B1、D3 和 E 的基因扩增和蛋白表达显著相关。cyclin A2 的过度表达与直肠癌的局部复发之间存在统计学上的显著关系，因为 cyclin A2 的高表达与较低的局部复发率相关。
