Department of General and Visceral Surgery, University Hospital Ulm, 89081 Ulm, Germany.
Research Group Oncology of Gastrointestinal Tumors (FOGT), University of Ulm, 89081 Ulm, Germany.
Int J Mol Sci. 2018 Aug 30;19(9):2577. doi: 10.3390/ijms19092577.
Colon cancer (CC) and rectal cancer (RC) are synonymously called colorectal cancer (CRC). Based on our experience in basic and clinical research as well as routine work in the field, the term CRC should be abandoned. We analyzed the available data from the literature and results from our multicenter Research Group Oncology of Gastrointestinal Tumors termed FOGT to confirm or reject this hypothesis. Anatomically, the risk of developing RC is four times higher than CC, while physical activity helps to prevent CC but not RC. Obvious differences exist in molecular carcinogenesis, pathology, surgical topography and procedures, and multimodal treatment. Therefore, we conclude that CC is not the same as RC. The term "CRC" should no longer be used as a single entity in basic and clinical research as well as other areas of classification.
结肠癌（CC）和直肠癌（RC）同义地称为结直肠癌（CRC）。根据我们在基础和临床研究以及该领域常规工作中的经验，CRC 这个术语应该被摒弃。我们分析了文献中的可用数据以及我们称之为 FOGT 的胃肠道肿瘤多中心研究小组的结果，以证实或否定这一假设。解剖学上，发展为 RC 的风险是 CC 的四倍，而体力活动有助于预防 CC，但不能预防 RC。在分子发生、病理学、外科解剖和程序以及多模式治疗方面存在明显差异。因此，我们得出结论，CC 与 RC 不同。在基础和临床研究以及其他分类领域，CRC 这个术语不应再作为一个单一实体使用。
