Saito T, Fukuda H, Arisue M, Matsuda A, Shindoh M, Amemiya A, Mizuno S
First Department of Oral Surgery, Hokkaido University School of Dentistry, Sapporo, Japan.
Oral Surg Oral Med Oral Pathol. 1991 Feb;71(2):179-83. doi: 10.1016/0030-4220(91)90462-l.
We studied 113 patients who were suspected to have Sjögren's syndrome (SS) because they had dry mouth and dry eyes, and who were determined as not having any other autoimmune disease, to clarify the relationship of periductal lymphocytic infiltration of salivary glands to clinical and immunologic findings in relation to SS. Periductal lymphocytic infiltrations were observed in the labial and/or the parotid glands of 57 patients (P-group). The salivary glands of the other 56 patients did not demonstrate obvious histologic changes (N-group). The stimulated salivary flow rate of parotid glands of the patients in both the P- and N-groups was significantly reduced when compared with healthy persons. However, no difference in the flow rate was observed between the P- and N-groups. In contrast, the percentage of patients in the P-group with keratoconjunctivitis sicca was significantly higher than that of patients in the N-group. Percentage of gamma-globulin fraction and IgG level in the sera of the patients in the P-group were both significantly higher than those in the N-group. The percentages of patients who demonstrated the serum rheumatoid factor, anti-SS-A, and anti-SS-B antibodies were also significantly higher in the P-group than in the N-group.
我们研究了113例因口干、眼干而疑似患有干燥综合征（SS）且被确定无其他自身免疫性疾病的患者，以阐明涎腺导管周围淋巴细胞浸润与SS相关的临床及免疫学表现之间的关系。在57例患者的唇腺和/或腮腺中观察到导管周围淋巴细胞浸润（P组）。其他56例患者的涎腺未显示明显的组织学改变（N组）。与健康人相比，P组和N组患者腮腺的刺激唾液流速均显著降低。然而，P组和N组之间在流速上未观察到差异。相比之下，P组中患有干燥性角结膜炎的患者百分比显著高于N组。P组患者血清中的γ-球蛋白分数和IgG水平均显著高于N组。P组中血清类风湿因子、抗SS-A和抗SS-B抗体阳性的患者百分比也显著高于N组。
