Farris R L, Stuchell R N, Nisengard R
Department of Ophthalmology, College of Physician and Surgeons, Columbia University, New York, NY.
Cornea. 1991 May;10(3):207-9. doi: 10.1097/00003226-199105000-00004.
Keratoconjunctivitis sicca patients diagnosed on the basis of a history, dry-eye symptoms, and definite clinical signs of keratoconjunctivitis sicca, with the associated symptoms of dry mouth and/or arthritis, had measurements of tear osmolarity, Schirmer tear test without anesthetic, stimulated parotid salivary flow, and serum analysis for the presence of autoantibodies associated with Sjogren's Syndrome. In contrast to previous studies, a lower incidence of SS-A or SS-B (1-3%), ANA (41-47%), DNA (11-16%), and RF (9-12%) serum antibodies was detected. Salivary-stimulated parotid flow was abnormally decreased in 59% of the patients. Sjogren's syndrome, as indicated by the presence of serum antibodies, appears to have a lower incidence in keratoconjunctivitis sicca than considered previously.
根据病史、干眼症状以及干燥性角结膜炎的确切临床体征确诊的干燥性角结膜炎患者，伴有口干和/或关节炎等相关症状，接受了泪液渗透压测量、无麻醉下的Schirmer泪液试验、刺激腮腺唾液流量测定以及血清分析以检测与干燥综合征相关的自身抗体。与先前的研究相比，检测到的SS-A或SS-B（1-3%）、ANA（41-47%）、DNA（11-16%）和RF（9-12%）血清抗体的发生率较低。59%的患者唾液刺激后的腮腺流量异常降低。血清抗体的存在表明，干燥性角结膜炎中干燥综合征的发病率似乎比先前认为的要低。
