Lassmann Hans
Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Wien, Austria.
Rinsho Shinkeigaku. 2009 Nov;49(11):900-1. doi: 10.5692/clinicalneurol.49.900.
Recently a specific auto-antibody response has been found in patients with neuromyelitis optica, which is directed against the astrocytic water channel aquaporin 4. In experimental models these antibodies do not induce disease or lesions in the central nervous system, when present in the circulation of normal rats. However, when T-cell mediated inflammation is induced in such animals, circulating antibodies against aquaporin 4 can reach the brain and induce lesions in the central nervous system, which are closely similar to those, seen in patients with neuromyelitis optica.
最近，在视神经脊髓炎患者中发现了一种针对星形胶质细胞水通道蛋白4的特异性自身抗体反应。在实验模型中，当这些抗体存在于正常大鼠的循环系统中时，不会诱发中枢神经系统疾病或病变。然而，当在此类动物中诱导T细胞介导的炎症时，循环中的抗水通道蛋白4抗体可进入大脑并诱发中枢神经系统病变，这些病变与视神经脊髓炎患者所见的病变极为相似。
