Illuminating neuromyelitis optica pathogenesis.
作者信息
Ransohoff Richard M
机构信息
Neuroinflammation Research Center, Cleveland Clinic, Cleveland, OH 44195, USA.
出版信息
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1001-2. doi: 10.1073/pnas.1119288109. Epub 2012 Jan 23.
Abstract
摘要
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Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes.视神经脊髓炎免疫球蛋白 G（NMO-IgG）与星形胶质细胞水通道蛋白 4 结合的分子结果。
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1245-50. doi: 10.1073/pnas.1109980108. Epub 2011 Nov 29.
2
[Experimental models of neuromyelitis optica].[视神经脊髓炎的实验模型]
Rinsho Shinkeigaku. 2009 Nov;49(11):900-1. doi: 10.5692/clinicalneurol.49.900.
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[Clinical overview of neuromyelitis optica].视神经脊髓炎临床概述
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Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2.视神经脊髓炎患者体内的水通道蛋白4结合自身抗体通过下调兴奋性氨基酸转运体2来损害谷氨酸转运。
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