Jelcić Jozo, Korsić Mirko
Zavod za endokrinologiju, Klinika za unutarnje bolesti Medicinskog fakulteta, KBC Zagreb.
Lijec Vjesn. 2009 Sep-Oct;131(9-10):279-85.
Obesity is one of the leading public health problems. Fat tissue is an organ with intensive metabolic activity whose function is to store unused energy. At the same time, it is a gland with internal secretion which secretes cytokines (adipokines) which have an endocrine, paracrine and autocrine function. Receptors for numerous hormones and cytokines are found on adipocytes. In such a way a functional connection between fat tissue and other tissues and organs is ensured. Fat tissue is part of a system of neuroendocrine regulation of body mass and metabolism. An increase in fat tissue, especially in visceral fat tissue, leads to an increase in adipokine blood concentration, which results in changes in the functioning of distant tissues and organs with which fat tissue is hormonally linked. The consequent comprehensive changes in the metabolism are termed metabolic syndrome, and are linked with further complications. The consequences of these complications are a diminished quality of life and a rise in mortality. The treatment of obesity is a long term and often unsuccessful process. Better results of treatment are achieved by a multidisciplinary approach.
肥胖是主要的公共卫生问题之一。脂肪组织是一个代谢活动旺盛的器官,其功能是储存未使用的能量。同时,它是一个具有内分泌功能的腺体,能分泌具有内分泌、旁分泌和自分泌功能的细胞因子(脂肪因子)。在脂肪细胞上发现了许多激素和细胞因子的受体。通过这种方式,确保了脂肪组织与其他组织和器官之间的功能联系。脂肪组织是体重和代谢神经内分泌调节系统的一部分。脂肪组织增加,尤其是内脏脂肪组织增加,会导致脂肪因子血液浓度升高,进而导致与脂肪组织有激素联系的远处组织和器官功能发生变化。随之而来的代谢全面变化被称为代谢综合征,并与进一步的并发症相关。这些并发症的后果是生活质量下降和死亡率上升。肥胖的治疗是一个长期且往往不成功的过程。多学科方法能取得更好的治疗效果。