Max-Planck-Institut für Molekulare Physiologie, Dortmund, Germany.
Biol Chem. 2010 May;391(5):491-7. doi: 10.1515/BC.2010.013.
Biology-oriented synthesis (BIOS) represents an alternative approach for the generation of compound collections for biological applications. In BIOS, biologically relevant and prevalidated scaffold structures, such as core structures of natural products or known drugs, are employed as scaffolds for the generation of compound collections with focused diversity. In this review, we discuss the underlying concept of the BIOS approach, and its practical implementation in library design and synthesis. To highlight its relevance for chemical biology applications, we finally present examples in which compound collections generated under the BIOS principle have been used to elucidate biological questions.
生物导向合成（BIOS）代表了一种用于生成用于生物应用的化合物库的替代方法。在 BIOS 中，采用生物学上相关且经过预先验证的支架结构，如天然产物或已知药物的核心结构，作为生成具有集中多样性的化合物库的支架。在这篇综述中，我们讨论了 BIOS 方法的基本概念及其在文库设计和合成中的实际应用。为了强调其在化学生物学应用中的相关性，我们最后介绍了在这些化合物库的生成中应用 BIOS 原理来阐明生物学问题的例子。
