Wilk Wolfram, Waldmann Herbert, Kaiser Markus
Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany.
Bioorg Med Chem. 2009 Mar 15;17(6):2304-9. doi: 10.1016/j.bmc.2008.11.001. Epub 2008 Nov 8.
In "Biology Oriented Synthesis" (BIOS), the inherent biological relevance of natural products is employed for the design and synthesis of compound libraries. Towards this end, library generation in BIOS is focused on compound classes from biologically relevant space such as the natural product space or also the drug space and only scaffolds of these areas of proven relevance are employed for synthesis of small focused libraries with limited diversity. We here present a short overview of gamma-pyrone natural products, highlighting their biological properties and their potential applicability in a BIOS of a compound library.
在“面向生物学的合成”（BIOS）中，天然产物固有的生物学相关性被用于化合物库的设计与合成。为此，BIOS中的库生成聚焦于来自生物学相关领域的化合物类别，如天然产物领域或药物领域，并且仅采用这些已证实具有相关性领域的骨架来合成具有有限多样性的小型聚焦库。我们在此简要概述γ-吡喃酮天然产物，重点介绍它们的生物学特性以及在化合物库BIOS中的潜在适用性。
