Departments of Psychiatry and Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA.
J Clin Psychiatry. 2009 Nov;70(11):e44. doi: 10.4088/JCP.8125tx9c.
Bipolar disorder is an increasingly common diagnosis given to children and adolescents. Most studies of lithium, anticonvulsants, and atypical antipsychotics have been conducted in adult populations, but new data are providing information on the safety and tolerability of these medications for treating children and adolescents. Although generally well tolerated, psychotropic agents have different side effect profiles that should be considered when planning treatment regimens for pediatric patients. Additional controlled and comparative trials are needed on the safety and tolerability of these medications in young patients, especially for long-term maintenance treatment.
双相情感障碍在儿童和青少年中的诊断越来越常见。大多数关于锂、抗惊厥药和非典型抗精神病药的研究都是在成年人群中进行的，但新的数据为这些药物治疗儿童和青少年的安全性和耐受性提供了信息。虽然通常耐受性良好，但精神药物具有不同的副作用特征，在为儿科患者制定治疗方案时应予以考虑。需要对这些药物在年轻患者中的安全性和耐受性进行更多的对照和比较试验，特别是对于长期维持治疗。
