Thomas Tiffany, Stansifer Libbie, Findling Robert L
Division of Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Cleveland, OH 44106-5080, USA.
Pediatr Clin North Am. 2011 Feb;58(1):173-87, xii. doi: 10.1016/j.pcl.2010.10.001.
Pediatric bipolar disorder (PBD) is a chronic and disabling illness often leading to serious disruption in the lives of children and adolescents with this condition. Until recently, methodologically stringent data to guide pharmacologic interventions in the youth were scarce. However, clinical trials conducted recently have expanded the existing evidence base, and new data are emerging rapidly. Recent studies have examined the use of lithium, anticonvulsants, and atypical antipsychotics for acute and long-term treatment of PBD. Despite these new advances, further placebo-controlled trials investigating the efficacy and safety of pharmacologic treatment strategies for young people with bipolar disorder are still needed.
小儿双相情感障碍（PBD）是一种慢性致残性疾病，常导致患有这种疾病的儿童和青少年的生活严重混乱。直到最近，用于指导青少年药物干预的方法严谨的数据还很匮乏。然而，最近进行的临床试验扩大了现有的证据基础，新数据也在迅速涌现。最近的研究探讨了锂盐、抗惊厥药和非典型抗精神病药在PBD急性和长期治疗中的应用。尽管有这些新进展，但仍需要进一步的安慰剂对照试验来研究双相情感障碍青少年药物治疗策略的疗效和安全性。
