Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN-00250 Helsinki, Finland.
J Clin Virol. 2010 Feb;47(2):186-8. doi: 10.1016/j.jcv.2009.11.028. Epub 2009 Dec 23.
The human bocavirus (HBoV), a newly discovered parvovirus, is closely related to the bovine parvovirus and the canine minute virus, which are known to cause adverse pregnancy outcomes. Another human parvovirus, B19, can lead to fetal hydrops, miscarriage and intrauterine fetal death (IUFD).
To determine the prevalence of HBoV DNA in aborted fetuses and IUFDs. The HBoV serology of the mothers was also studied.
We retrospectively studied all available fetuses (N=535) autopsied during 7/1992-12/1995, and 1/2003-12/2005 in Helsinki, Finland. All available formalin-fixed paraffin-embedded fetal tissues - placenta, heart and liver - of 120 miscarriages, 169 IUFDs, and 246 induced abortions were studied by quantitative PCR. We also measured the HBoV IgM and IgG antibodies in the corresponding maternal sera (N=462) mostly of the first trimester. The IgM-positive sera underwent HBoV PCR.
None of the fetal tissues harbored HBoV DNA. A total of 97% (448/462) of the mothers were positive for IgG antibodies to HBoV, while only 0.9% (4/462) exhibited HBoV-specific IgM antibodies without viremia or respiratory symptoms. One IgM-positive mother had an unexplained fetal loss.
We did not find HBoV DNA in any of the deceased fetuses. Almost all pregnant women were HBoV-IgG positive.
人类博卡病毒（HBoV）是一种新发现的细小病毒，与牛细小病毒和犬细小病毒密切相关，已知这些病毒会导致不良的妊娠结局。另一种人类细小病毒 B19 可导致胎儿水肿、流产和宫内胎儿死亡（IUFD）。
确定 HBoV DNA 在流产胎儿和 IUFD 中的流行率。还研究了母亲的 HBoV 血清学。
我们回顾性研究了芬兰赫尔辛基在 1992 年 7 月至 1995 年 12 月和 2003 年 1 月至 2005 年 12 月期间所有可获得的 535 例尸检胎儿。通过定量 PCR 研究了 120 例流产、169 例 IUFD 和 246 例人工流产的所有可获得的福尔马林固定石蜡包埋胎儿组织（胎盘、心脏和肝脏）。我们还测量了相应的母体血清（N=462）中的 HBoV IgM 和 IgG 抗体，这些血清大多来自妊娠早期。HBoV 阳性的 IgM 血清进行了 HBoV PCR。
胎儿组织中均未检测到 HBoV DNA。462 例母亲中，共有 97%（448/462）对 HBoV 产生 IgG 抗体，而只有 0.9%（4/462）产生 HBoV 特异性 IgM 抗体而无病毒血症或呼吸道症状。一位 IgM 阳性的母亲发生了不明原因的胎儿丢失。
我们未在任何死亡胎儿中发现 HBoV DNA。几乎所有孕妇均对 HBoV IgG 呈阳性。
