Go Alan S, Magid David J, Wells Barbara, Sung Sue Hee, Cassidy-Bushrow Andrea E, Greenlee Robert T, Langer Robert D, Lieu Tracy A, Margolis Karen L, Masoudi Frederick A, McNeal Catherine J, Murata Glen H, Newton Katherine M, Novotny Rachel, Reynolds Kristi, Roblin Douglas W, Smith David H, Vupputuri Suma, White Robert E, Olson Jean, Rumsfeld John S, Gurwitz Jerry H
Kaiser Permanente Northern California, University of California, San Francisco, Calif, USA.
Circ Cardiovasc Qual Outcomes. 2008 Nov;1(2):138-47. doi: 10.1161/CIRCOUTCOMES.108.801654.
A clear need exists for a more systematic understanding of the epidemiology, diagnosis, and management of cardiovascular diseases. More robust data are also needed on how well clinical trials are translated into contemporary community practice and the associated resource use, costs, and outcomes.
The National Heart, Lung, and Blood Institute recently established the Cardiovascular Research Network, which represents a new paradigm to evaluate the epidemiology, quality of care, and outcomes of cardiovascular disease and to conduct future clinical trials using a community-based model. The network includes 15 geographically distributed health plans with dedicated research centers, National Heart, Lung, and Blood Institute representatives, and an external collaboration and advisory committee. Cardiovascular research network sites bring complementary content and methodological expertise and a diverse population of approximately 11 million individuals treated through various health care delivery models. Each site's rich electronic databases (eg, sociodemographic characteristics, inpatient and outpatient diagnoses and procedures, pharmacy, laboratory, and cost data) are being mapped to create a standardized virtual data warehouse to facilitate rapid and efficient large-scale research studies. Initial projects focus on (1) hypertension recognition and management, (2) quality and outcomes of warfarin therapy, and (3) use, outcomes, and costs of implantable cardioverter defibrillators.
The Cardiovascular Research Network represents a new paradigm in the approach to cardiovascular quality of care and outcomes research among community-based populations. Its unique ability to characterize longitudinally large, diverse populations will yield novel insights into contemporary disease and risk factor surveillance, management, outcomes, and costs. The Cardiovascular Research Network aims to become the national research partner of choice for efforts to improve the prevention, diagnosis, treatment, and outcomes of cardiovascular diseases.
目前显然需要更系统地了解心血管疾病的流行病学、诊断和管理。还需要更有力的数据来了解临床试验在当代社区实践中的转化情况以及相关的资源使用、成本和结果。
美国国立心肺血液研究所最近建立了心血管研究网络，这代表了一种新的模式，用于评估心血管疾病的流行病学、医疗质量和结果，并使用基于社区的模式开展未来的临床试验。该网络包括15个地理分布广泛的健康计划，这些计划设有专门的研究中心、国立心肺血液研究所代表以及一个外部合作与咨询委员会。心血管研究网络站点带来了互补的内容和方法学专业知识，以及通过各种医疗服务模式接受治疗的约1100万不同人群。每个站点丰富的电子数据库（如社会人口统计学特征、住院和门诊诊断及程序、药房、实验室和成本数据）正在进行映射，以创建一个标准化的虚拟数据仓库，便于快速高效地开展大规模研究。初始项目聚焦于：（1）高血压的识别与管理；（2）华法林治疗的质量和结果；（3）植入式心律转复除颤器的使用、结果和成本。
心血管研究网络代表了基于社区人群的心血管医疗质量和结果研究方法的一种新模式。其独特的纵向描述大量不同人群的能力将为当代疾病及危险因素监测、管理、结果和成本带来新的见解。心血管研究网络旨在成为改善心血管疾病预防、诊断、治疗和结果工作的首选国家研究合作伙伴。
