Holt Peter J E, Poloniecki Jan D, Khalid Usman, Hinchliffe Robert J, Loftus Ian M, Thompson Matt M
Department of Outcomes Research, St George's Vascular Institute, London; and Community Health Sciences, St George's University of London, United Kingdom.
Circ Cardiovasc Qual Outcomes. 2009 Nov;2(6):624-32. doi: 10.1161/CIRCOUTCOMES.109.848465. Epub 2009 Sep 22.
We aim to quantify the relationship between the annual caseload (volume) and outcome from elective endovascular (EVR) or open repair of abdominal aortic aneurysms (AAAs) in England between 2005 and 2007.
Individual patient data were obtained from the Hospital Episode Statistics. Statistical methods included multiple logistic regression models, mortality control charts, and safety plots to determine the nature of any relationship between volume and outcome. The case-mix between hospitals of different sizes was examined using observed and expected values for in-hospital mortality. Outcome measures included in-hospital mortality and hospital length of stay. Between 2005 and 2007, a total of 57 587 patients were admitted to hospitals in England with a diagnosis of AAA, and 11 574 underwent AAA repair. There were 7313 elective AAA repairs, of which 5668 (78%) were open and 1645 (22%) were EVR. In-hospital mortality rates were 5.63% for all elective AAA repairs with rates of 6.18% for open repair and 3.77% for EVR (odds ratio, 0.676; 95% CI, 0.501 to 0.913; P=0.011). High-volume aneurysm services were associated with significantly lower mortality rates overall (0.991; 0.988 to 0.994; P<0.0001), for open repairs (0.994; 0.991 to 0.998; P=0.0008), and EVR (0.989; 0.982 to 0.995; P=0.0007). Large endovascular units had low mortality rates for open repairs.
A strong relationship existed between the volume of surgery performed and outcome from both open and endovascular aneurysm repairs. These data support the concept that abdominal aortic surgery should be performed in specialized units that meet a minimum volume threshold.
我们旨在量化2005年至2007年间英格兰腹主动脉瘤(AAA)择期血管内修复术(EVR)或开放修复术的年病例数(手术量)与预后之间的关系。
从医院事件统计数据中获取个体患者数据。统计方法包括多重逻辑回归模型、死亡率控制图和安全性图,以确定手术量与预后之间任何关系的性质。使用观察到的和预期的院内死亡率来检查不同规模医院之间的病例组合。预后指标包括院内死亡率和住院时间。2005年至2007年间,英格兰共有57587例诊断为AAA的患者入院,其中11574例接受了AAA修复。有7313例择期AAA修复,其中5668例(78%)为开放修复,1645例(22%)为EVR。所有择期AAA修复的院内死亡率为5.63%,开放修复的死亡率为6.18%,EVR的死亡率为3.77%(比值比,0.676;95%可信区间,0.501至0.913;P = 0.011)。总体而言,高手术量的动脉瘤治疗服务与显著较低的死亡率相关(0.991;0.988至0.994;P < 0.0001),开放修复(0.994;0.991至0.998;P = 0.0008)和EVR(0.989;0.982至0.995;P = 0.0007)。大型血管内治疗单位开放修复的死亡率较低。
手术量与开放和血管内动脉瘤修复的预后之间存在密切关系。这些数据支持腹主动脉手术应在达到最低手术量阈值的专科单位进行的概念。