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破裂性腹主动脉瘤治疗结局的倾向性评分分析。

Propensity scored analysis of outcomes after ruptured abdominal aortic aneurysm.

机构信息

Department of Outcomes Research, St George's Vascular Institute, London, UK.

出版信息

Br J Surg. 2010 Apr;97(4):496-503. doi: 10.1002/bjs.6911.

Abstract

BACKGROUND

This study examined the population outcome of ruptured abdominal aortic aneurysm (rAAA) in England, the role of endovascular repair (EVAR), and the relationship between outcome and hospital workload.

METHODS

Data were retrieved from Hospital Episode Statistics between 1 April 2003 and 31 March 2008. Propensity scoring was used to compare the outcomes of stratified patients undergoing EVAR and open repair. The relationship between workload and outcome was determined.

RESULTS

Some 3725 urgent and 4414 rAAA repairs were included. Mortality rates were 21.3 per cent for urgent repair and 46.3 per cent for rAAA repair. EVAR was employed for 16.3 and 7.6 per cent of urgent and rAAA repairs respectively. EVAR was associated with significantly reduced mortality for urgent repair (odds ratio (OR) 0.531, 95 per cent confidence interval 0.415 to 0.680; P < 0.001) and rAAA repair (OR 0.527, 0.416 to 0.668; P < 0.001). A propensity scored analysis confirmed the benefit of EVAR for rAAA repair (P < 0.001). Repair of rAAA at hospitals with a higher elective aneurysm workload was associated with lower mortality rates irrespective of the mode of treatment (P < 0.001). Higher-volume hospitals were more likely to operate on rAAA (P = 0.033).

CONCLUSION

EVAR offered a survival advantage over open repair for non-elective aneurysm procedures. Services for the treatment of rAAA should incorporate access to EVAR and would benefit from being based in units with a high elective caseload.

摘要

背景

本研究考察了英国破裂性腹主动脉瘤(rAAA)的人群结局、血管内修复术(EVAR)的作用以及结局与医院工作量之间的关系。

方法

数据来源于 2003 年 4 月 1 日至 2008 年 3 月 31 日的医院住院统计数据。采用倾向评分法比较接受 EVAR 和开放修复的分层患者的结局。确定工作量与结局之间的关系。

结果

共纳入 3725 例急症和 4414 例 rAAA 修复术。急症修复术的死亡率为 21.3%,rAAA 修复术的死亡率为 46.3%。分别有 16.3%和 7.6%的急症和 rAAA 修复术采用了 EVAR。EVAR 与急症修复术(比值比(OR)0.531,95%置信区间 0.415 至 0.680;P < 0.001)和 rAAA 修复术(OR 0.527,0.416 至 0.668;P < 0.001)的死亡率显著降低相关。倾向评分分析证实了 EVAR 对 rAAA 修复术的获益(P < 0.001)。无论治疗方式如何,在择期动脉瘤工作量较高的医院对 rAAA 进行修复与较低的死亡率相关(P < 0.001)。高容量医院更有可能对 rAAA 进行手术(P = 0.033)。

结论

EVAR 为非择期动脉瘤手术提供了优于开放修复的生存优势。rAAA 的治疗服务应包括 EVAR,并受益于建立在高择期病例量的单位。

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