Jung L J, Scheller R H
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, CA 94305.
Science. 1991 Mar 15;251(4999):1330-5. doi: 10.1126/science.2003219.
The abdominal ganglion of the marine mollusk Aplysia contains a pair of identified neuronal clusters, the bag cells, which control egg laying by means of a number of unique regulatory mechanisms. Each neuron in the bag cell clusters synthesizes several peptides derived from a single prohormone and packages them into separate vesicles. These vesicles are then differentially localized in specific neuronal processes, thus segregating peptides destined for autocrine and hormonal release sites. Therefore in this system, protein trafficking through the secretory pathway organizes multiple peptide neurochemical messengers to efficiently regulate simple behaviors.
海洋软体动物海兔的腹神经节包含一对已确定的神经元簇,即袋状细胞,它们通过多种独特的调节机制控制产卵。袋状细胞簇中的每个神经元都能合成几种源自单一前体激素的肽,并将它们包装到不同的囊泡中。然后这些囊泡在特定的神经突中差异定位,从而将 destined for autocrine 和激素释放位点的肽分隔开来。因此,在这个系统中,通过分泌途径的蛋白质运输组织多种肽神经化学信使,以有效地调节简单行为。
原文中“destined for autocrine”表述不太完整准确,可能影响整体理解,但按照要求准确翻译了现有内容。