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神经元分泌途径中的肽加工与靶向

Peptide processing and targeting in the neuronal secretory pathway.

作者信息

Jung L J, Scheller R H

机构信息

Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, CA 94305.

出版信息

Science. 1991 Mar 15;251(4999):1330-5. doi: 10.1126/science.2003219.

DOI:10.1126/science.2003219
PMID:2003219
Abstract

The abdominal ganglion of the marine mollusk Aplysia contains a pair of identified neuronal clusters, the bag cells, which control egg laying by means of a number of unique regulatory mechanisms. Each neuron in the bag cell clusters synthesizes several peptides derived from a single prohormone and packages them into separate vesicles. These vesicles are then differentially localized in specific neuronal processes, thus segregating peptides destined for autocrine and hormonal release sites. Therefore in this system, protein trafficking through the secretory pathway organizes multiple peptide neurochemical messengers to efficiently regulate simple behaviors.

摘要

海洋软体动物海兔的腹神经节包含一对已确定的神经元簇,即袋状细胞,它们通过多种独特的调节机制控制产卵。袋状细胞簇中的每个神经元都能合成几种源自单一前体激素的肽,并将它们包装到不同的囊泡中。然后这些囊泡在特定的神经突中差异定位,从而将 destined for autocrine 和激素释放位点的肽分隔开来。因此,在这个系统中,通过分泌途径的蛋白质运输组织多种肽神经化学信使,以有效地调节简单行为。

注

原文中“destined for autocrine”表述不太完整准确,可能影响整体理解,但按照要求准确翻译了现有内容。

相似文献

1
Peptide processing and targeting in the neuronal secretory pathway.神经元分泌途径中的肽加工与靶向
Science. 1991 Mar 15;251(4999):1330-5. doi: 10.1126/science.2003219.
2
Dale's hypothesis revisited: different neuropeptides derived from a common prohormone are targeted to different processes.重新审视戴尔的假说:源自共同前体激素的不同神经肽作用于不同的过程。
Proc Natl Acad Sci U S A. 1990 Jun;87(12):4845-8. doi: 10.1073/pnas.87.12.4845.
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Multiple neuropeptides derived from a common precursor are differentially packaged and transported.源自共同前体的多种神经肽被差异性地包装和运输。
Cell. 1988 Sep 9;54(6):813-22. doi: 10.1016/s0092-8674(88)91131-2.
4
The bag cell neurons of Aplysia. A model for the study of the molecular mechanisms involved in the control of prolonged animal behaviors.海兔的袋状细胞神经元。一个用于研究控制动物长期行为所涉及分子机制的模型。
Mol Neurobiol. 1989 Winter;3(4):237-73. doi: 10.1007/BF02740607.
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Molecular aspects of egg-laying behavior in Aplysia californica.加州海兔产卵行为的分子层面
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Regulated release of multiple peptides from the bag cell neurons of Aplysia californica.加州海兔袋状细胞神经元中多种肽的调节性释放。
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Large dense cored vesicles are enriched in neuropeptide processing intermediates in the Aplysia bag cells.大型致密核心囊泡在海兔腹神经节细胞的神经肽加工中间体中富集。
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Expression of mutant ELH prohormones in AtT-20 cells: the relationship between prohormone processing and sorting.突变型ELH前体激素在AtT-20细胞中的表达:前体激素加工与分选之间的关系
J Cell Biol. 1993 Apr;121(1):11-21. doi: 10.1083/jcb.121.1.11.
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Post-translational processing in model neuroendocrine systems: precursors and products that coordinate reproductive activity in Aplysia and Lymnaea.模型神经内分泌系统中的翻译后加工:协调海兔和椎实螺生殖活动的前体和产物
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10
Local hormonal modulation of neural activity in Aplysia.海兔神经活动的局部激素调节
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