Turrisi A T
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor 48109.
Semin Oncol. 1991 Feb;18(1 Suppl 3):81-7.
Combined-modality therapy in lung cancer is a common practice throughout the world. The use of radiochemotherapy appears to be firmly established in the treatment of small cell lung cancer, but the role of prophylactic cranial irradiation remains undecided. Many recommend its use in the treatment of non-small cell lung cancer as well, but no facts exist to support this position. Because of poor long-term outcome and high frequency of systemic relapse, integration of chemotherapy for the treatment of non-small cell lung cancer is becoming more prevalent. This article discusses methods of integration, the problems of combined- modality toxicity, recent trials, and reports of multimodal therapy in lung cancer. The advantages of certain regimens of chemotherapy and new methods of radiotherapy are also discussed.
肺癌的综合治疗在全球都是一种常见的治疗方法。放化疗在小细胞肺癌治疗中的应用似乎已得到确立，但预防性颅脑照射的作用仍未确定。许多人也建议将其用于非小细胞肺癌的治疗，但尚无事实支持这一观点。由于长期预后较差且全身复发频率较高，化疗用于非小细胞肺癌治疗的整合正变得越来越普遍。本文讨论了整合方法、联合治疗毒性问题、近期试验以及肺癌多模式治疗的报告。还讨论了某些化疗方案的优势和放疗新方法。
