体外暴露于 2.3GHz 射频辐射对人淋巴细胞的细胞遗传学效应。
Cytogenetic effects of exposure to 2.3 GHz radiofrequency radiation on human lymphocytes in vitro.
机构信息
Department of Research and Development, The Cancer Center, Oslo University Hospital, Ulleval, 0407 Oslo, Norway.
出版信息
Anticancer Res. 2009 Nov;29(11):4323-30.
BACKGROUND
No previous in vitro studies have tested radio frequency radiation for at least one full cell cycle in culture. The aim was to test if exposure used in mobile phones and wireless network technologies would induce DNA damage in cultured human lymphocytes with and without a known clastogen.
MATERIALS AND METHODS
Lymphocytes from six donors were exposed to 2.3 GHz, 10 W/m(2) continuous waves, or 2.3 GHz, 10 W/m(2) pulsed waves (200 Hz pulse frequency, 50% duty cycle). Mitomycin C was added to half of the cultures. DNA synthesis and repair were inhibited in one experiment.
RESULTS
No statistically significant differences were observed between control and exposed cultures. A weak trend for more chromosomal damage with the interaction of pulsed fields with mitomycin C compared to a constant field was observed.
CONCLUSION
Exposure during the whole cell cycle in inhibited cultures did not resulted in significant differences in chromosomal aberrations as compared to controls.
背景
以前没有体外研究在培养过程中至少进行一个完整的细胞周期的射频辐射测试。本研究旨在测试在使用手机和无线网络技术中使用的辐射是否会在培养的人类淋巴细胞中引起 DNA 损伤，无论是否存在已知的致裂剂。
材料与方法
来自六位供体的淋巴细胞分别暴露于 2.3GHz、10W/m(2)连续波或 2.3GHz、10W/m(2)脉冲波（200Hz 脉冲频率，50%占空比）。一半的培养物中加入丝裂霉素 C。在一项实验中抑制了 DNA 合成和修复。
结果
与对照培养物相比，未观察到暴露培养物与对照培养物之间存在统计学显著差异。与恒定场相比，与丝裂霉素 C 共同作用的脉冲场显示出染色体损伤的微弱趋势。
结论
在抑制的培养物中整个细胞周期的暴露并未导致染色体畸变与对照相比有显著差异。
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