Department of Surgery, Showa University Fujigaoka Hospital, Aoba-ku, Yokohama 227-8501, Japan.
Anticancer Res. 2009 Nov;29(11):4397-9.
UNC5C, one of the netrin-1 receptors, belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Recently, aberrant methylation of the UNC5C gene was found in 34 out of 49 (69%) primary colon carcinomas.
The methylation status of the UNC5C gene was examined in primary carcinomas and the corresponding normal tissues derived from 36 patients with gastric cancer using quantitative methylation-specific polymerase chain reaction, and the correlation between the methylation status and the clinicopathological findings was evaluated.
Aberrant methylation of the UNC5C gene was detected in 9 out of the 36 (25%) primary gastric carcinomas. A significant difference was observed in regard to the TNM stage (p=0.0455).
UNC5C methylation was observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.
UNC5C 是 netrin-1 受体之一，属于功能依赖性受体家族，该家族成员在缺乏配体的情况下能够诱导细胞凋亡。最近，在 49 例原发性结肠癌中的 34 例（69%）中发现 UNC5C 基因异常甲基化。
采用定量甲基化特异性聚合酶链反应检测 36 例胃癌患者的原发性癌及相应正常组织中 UNC5C 基因的甲基化状态，并评估其与临床病理特征的相关性。
在 36 例原发性胃癌中有 9 例（25%）检测到 UNC5C 基因异常甲基化。在 TNM 分期方面有显著差异（p=0.0455）。
UNC5C 甲基化发生在胃癌发生发展过程中，在高度进展的胃癌中消失。
