Department of Health Sciences, University of Jaén, Campus Universitario Las Lagunillas, E-23071, Jaén, Spain.
Anticancer Res. 2009 Nov;29(11):4633-7.
A local renin-angiotensin system (RAS) has been found in ovary. This ovarian RAS may regulate ovarian steroidogenesis. Ample studies show that the ovarian hormones estradiol (E2) and progesterone (P) are strongly implicated in the development of breast cancer.
The aim of the present work was to elucidate if alterations in ovarian RAS, analyzed through their proteolytic regulatory enzymes aminopeptidase A (APA), B (APB) and N (APN), could be responsible for an altered steroidogenesis in rats with mammary tumours induced by N-methyl nitrosourea (NMU).
We describe here a highly significant increase of serum P levels in NMU-treated rats, concomitantly with an increase in ovarian aspartyl and glutamyl aminopeptidase activities (named together as APA activity). Moreover, we did not find changes in APB or APN activities, suggesting an increased metabolism from Ang II to Ang III and a decreased catabolism of Ang III.
The relationship between ovarian RAS and P overproduction in a rat model of mammary carcinogenesis indicates ovarian RAS as a new potential target in breast cancer therapy.
已在卵巢中发现局部肾素-血管紧张素系统（RAS）。该卵巢 RAS 可能调节卵巢甾体生成。大量研究表明，卵巢激素雌二醇（E2）和孕酮（P）强烈参与乳腺癌的发展。
本研究的目的是阐明，如果通过其蛋白水解调节酶氨基肽酶 A（APA）、B（APB）和 N（APN）分析的卵巢 RAS 发生改变，是否可能导致 N-甲基亚硝脲（NMU）诱导的乳腺癌大鼠的甾体生成发生改变。
我们在这里描述了 NMU 处理大鼠血清 P 水平的显著升高，同时卵巢天冬氨酰和谷氨酰氨基肽酶活性（统称为 APA 活性）增加。此外，我们没有发现 APB 或 APN 活性的变化，这表明 Ang II 向 Ang III 的代谢增加和 Ang III 的分解代谢减少。
在乳腺癌发生的大鼠模型中，卵巢 RAS 与 P 过度产生之间的关系表明卵巢 RAS 是乳腺癌治疗的一个新的潜在靶点。
