Experimental and Clinical Physiopathology Research Group, Department of Health Sciences, Faculty of Experimental and Health Sciences, University of Jaén, Jaén, Spain.
Life Sci. 2013 Dec 18;93(25-26):1004-9. doi: 10.1016/j.lfs.2013.10.018. Epub 2013 Oct 29.
An association between breast cancer and thyroid dysfunction exists although the underlying mechanisms remain to be elucidated. Numerous studies have characterized the role of thyroid hormones in controlling the synthesis and secretion of renin-angiotensin system (RAS) components, but little information is available on the putative role of the local RAS on thyroid function.
Here we analyze several soluble and membrane-bound RAS-regulating aminopeptidase activities in thyroid gland from rats with mammary tumors and the relationship with the circulating levels of thyroid stimulating hormone (TSH) and free thyroxin (fT4).
We analyze soluble and membrane-bound RAS-regulating aminopeptidase activities fluorometrically using their corresponding aminoacyl-β-naphthylamide as the substrate.
We have found in rats with mammary tumors a concomitant change of thyroid RAS-regulating enzymes and thyroid hormone production.
We suggest that existence of alterations in the regulatory mechanisms mediated by the angiotensins of the local tissue RAS as a consequence of the carcinogenic process which could act alone or in combination with alterations at a higher level of regulation such as the hypothalamus-pituitary axis.
乳腺癌与甲状腺功能障碍之间存在关联，尽管其潜在机制仍有待阐明。许多研究已经描述了甲状腺激素在控制肾素-血管紧张素系统 (RAS) 成分的合成和分泌中的作用，但关于局部 RAS 对甲状腺功能的潜在作用的信息很少。
在这里，我们分析了来自患有乳腺癌的大鼠甲状腺中的几种可溶性和膜结合的 RAS 调节氨肽酶活性，以及它们与循环促甲状腺激素 (TSH) 和游离甲状腺素 (fT4) 水平的关系。
我们使用相应的氨酰基-β-萘基酰胺作为底物，通过荧光法分析可溶性和膜结合的 RAS 调节氨肽酶活性。
我们在患有乳腺癌的大鼠中发现了甲状腺 RAS 调节酶和甲状腺激素产生的同时变化。
我们认为，局部组织 RAS 的血管紧张素介导的调节机制的改变可能是由于致癌过程引起的，这些改变可能单独作用或与更高水平的调节改变（如下丘脑-垂体轴）相结合。
Zotero 插件