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严重髋膝关节骨关节炎患者在等待关节置换术中的骨质疏松症患病率。

The prevalence of osteoporosis in patients with severe hip and knee osteoarthritis awaiting joint arthroplasty.

机构信息

Department of Orthopaedic Surgery, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK.

出版信息

Age Ageing. 2010 Mar;39(2):234-9. doi: 10.1093/ageing/afp222. Epub 2009 Dec 23.

Abstract

BACKGROUND

the presence of osteoporosis in patients with hip and knee osteoarthritis (OA) has important implications for understanding disease progression and providing optimal surgical and medical management.

OBJECTIVE

to determine the prevalence of osteoporosis among patients with osteoarthritis awaiting total knee arthroplasty or total hip arthroplasty aged between 65 and 80 years.

DESIGN

cross-sectional observational study.

SETTING

tertiary referral centre in Newcastle upon Tyne, UK.

SUBJECTS

patients with osteoarthritis awaiting total knee hip arthroplasty aged between 65 and 80 years.

METHODS

lumbar spine, bilateral femoral and forearm bone mineral density (BMD) measurements were obtained using dual-energy X-ray absorptiometry.

RESULTS

the cohort consisted of 199 patients with a mean age of 72 years (SD 4), and 113 (57%) were women. The overall rate of osteoporosis at any site was 23% (46/199) and a further 43% (85/199) of patients would have been classified as osteopaenic according to World Health Organization criteria. Osteoporosis was more commonly detected in the forearm (14%) than the lumbar spine (8.5%) and proximal femur of the index side (8.2%).

CONCLUSIONS

in summary, a significant proportion of patients with end-stage OA have osteoporosis but this diagnosis may be missed unless BMD measurements are performed at sites distant from joints affected by OA.

摘要

背景

患有髋膝关节骨关节炎(OA)的患者存在骨质疏松症,这对了解疾病进展和提供最佳手术和医疗管理具有重要意义。

目的

确定 65 至 80 岁之间接受全膝关节置换术或全髋关节置换术的 OA 患者中骨质疏松症的患病率。

设计

横断面观察性研究。

地点

英国泰恩河畔纽卡斯尔的三级转诊中心。

受试者

65 至 80 岁之间接受全膝关节髋关节置换术的 OA 患者。

方法

使用双能 X 射线吸收法测量腰椎、双侧股骨和前臂骨密度(BMD)。

结果

该队列包括 199 名平均年龄为 72 岁(SD 4)的患者,其中 113 名(57%)为女性。任何部位骨质疏松症的总体发生率为 23%(46/199),根据世界卫生组织标准,另有 43%(85/199)的患者将被归类为骨质疏松症。骨质疏松症在手前臂(14%)比腰椎(8.5%)和索引侧股骨近端(8.2%)更常见。

结论

总之,相当一部分终末期 OA 患者患有骨质疏松症,但除非在远离 OA 受累关节的部位进行 BMD 测量,否则可能会漏诊该诊断。

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