Boehme Richard E, Cameron Stephen
International Medical Press, Hamilton, NJ, USA.
Antivir Ther. 2009;14(8):1195-208. doi: 10.3851/IMP1470.
The effectiveness of current antiretroviral therapies has led to more patients receiving long-term therapy, and increasing numbers of older patients. The complex interactions between HIV infection, ageing, comorbid conditions and drug-related toxicities, and their combined effects on patient health and quality of life, were the subject of the 11th International Workshop on Adverse Drug Reactions and Co-Morbidities in HIV. Key topics included the metabolic effects of antiretroviral agents, cardiovascular disease, bone metabolism and age-related changes in disease and response to drug therapy. Data presented at the meeting reflect the growing recognition of common pathways that contribute to progression of mutiple types of disease and adverse drug reactions.
目前抗逆转录病毒疗法的有效性使得更多患者接受长期治疗，老年患者的数量也在增加。HIV感染、衰老、合并症和药物相关毒性之间的复杂相互作用，以及它们对患者健康和生活质量的综合影响，是第11届HIV药物不良反应和合并症国际研讨会的主题。关键主题包括抗逆转录病毒药物的代谢影响、心血管疾病、骨代谢以及疾病的年龄相关变化和对药物治疗的反应。会议上展示的数据反映出人们越来越认识到导致多种疾病进展和药物不良反应的共同途径。
